2-[4-[2-[2-Amino-3',6'-bis(dimethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-5-yl]ethynyl]phenyl]-6-(dimethylamino)benzo[de]isoquinoline-1,3-dione | 1420536-08-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[4-[2-[2-Amino-3',6'-bis(dimethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-5-yl]ethynyl]phenyl]-6-(dimethylamino)benzo[de]isoquinoline-1,3-dione
• 英文别名: 2-[4-[2-[2-amino-3',6'-bis(dimethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-5-yl]ethynyl]phenyl]-6-(dimethylamino)benzo[de]isoquinoline-1,3-dione
• CAS: 1420536-08-8
• 化学式: C₄₆H₃₈N₆O₄
• 分子量: 738.846
• InChiKey: CXYFJSZNEPMRKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  56
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3-羟基-N,N-二甲基苯胺 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 一水合肼 、 丙酸 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 43.0h， 生成 2-[4-[2-[2-Amino-3',6'-bis(dimethylamino)-3-oxospiro[isoindole-1,9'-xanthene]-5-yl]ethynyl]phenyl]-6-(dimethylamino)benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  A Fluorescent Ratiometric Chemodosimeter for Cu²⁺ Based on TBET and Its Application in Living Cells

  摘要：

  Based on a through bond energy transfer (TBET) between Rhodamlne and a naphthalimide fluorophore, a fluorescent ratiometric chemodosimeter AM was designed and prepared for single selective detection of Cu2+ in aqueous solution and in living cells, as Cu2+ acts as not only a selective recognizing guest but also a hydrolytic promoter.

  DOI：

  10.1021/ol3032889

文献信息

• A Fluorescent Ratiometric Chemodosimeter for Cu²⁺ Based on TBET and Its Application in Living Cells
  作者：Jiangli Fan、Peng Zhan、Mingming Hu、Wen Sun、Jizhou Tang、Jingyun Wang、Shiguo Sun、Fengling Song、Xiaojun Peng

  DOI：10.1021/ol3032889

  日期：2013.2.1

  Based on a through bond energy transfer (TBET) between Rhodamlne and a naphthalimide fluorophore, a fluorescent ratiometric chemodosimeter AM was designed and prepared for single selective detection of Cu2+ in aqueous solution and in living cells, as Cu2+ acts as not only a selective recognizing guest but also a hydrolytic promoter.