3-[5-[2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-3-pent-4-enylfuran-2-yl]phenol | 1204300-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-[5-[2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-3-pent-4-enylfuran-2-yl]phenol
• 英文别名: 3-[5-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]-3-pent-4-enylfuran-2-yl]phenol
• CAS: 1204300-08-2
• 化学式: C₂₃H₂₄O₄
• 分子量: 364.441
• InChiKey: HQPIUJXIJKOIEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  73.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,6-Bis(3-hydroxyphenyl)-2-pent-4-enylidenehex-3-yne-1,6-diol 在 chloro(triphenylphosphine)silver(I) 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到3-[5-[2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-3-pent-4-enylfuran-2-yl]phenol
  参考文献：
  名称：

  Gold-catalyzed cyclization of enyne-1,6-diols to substituted furans

  摘要：

  Treatment of enyne-1,6-diols with 5 mol % Ph3PAuCl in the presence of 5 mol % AgOTf as a cocatalyst selectively produced trisubstituted furans in good to excellent yields in dichloromethane at room temperature for 5-10 min through cyclization followed by isomerization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.026

文献信息

• Gold-catalyzed cyclization of enyne-1,6-diols to substituted furans
  作者：Sundae Kim、Dongjin Kang、Seunghoon Shin、Phil Ho Lee

  DOI：10.1016/j.tetlet.2010.02.026

  日期：2010.4

  Treatment of enyne-1,6-diols with 5 mol % Ph3PAuCl in the presence of 5 mol % AgOTf as a cocatalyst selectively produced trisubstituted furans in good to excellent yields in dichloromethane at room temperature for 5-10 min through cyclization followed by isomerization. (C) 2010 Elsevier Ltd. All rights reserved.