2-Ethyloxan-4-amine | 1334147-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-Ethyloxan-4-amine
• CAS: 1334147-26-0
• 化学式: C₇H₁₅NO
• mdl: MFCD19650473
• 分子量: 129.2
• InChiKey: UXZVPCXTWGZXHH-UHFFFAOYSA-N

物化性质

• 沸点：
  185.4±33.0 °C(Predicted)
• 密度：
  0.905±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)<br/>[FR] INHIBITEUR DE L'INDOLÉAMINE-2,3-DIOXYGÉNASE (IDO)
  申请人：INVENTISBIO INC

  公开号：WO2017139414A1

  公开（公告）日：2017-08-17

  The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

  本公开提供了式（I）的化合物。本文描述的化合物可能在治疗与IDO相关的疾病方面有用，例如癌症或传染病（例如病毒或细菌感染性疾病）。本公开还提供了包括或使用本文描述的化合物的药物组合物、试剂盒、方法和用途。
• Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same
  申请人：Nishino Shigeyoshi

  公开号：US20070106083A1

  公开（公告）日：2007-05-10

  The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.

  本发明涉及一种制备4-氨基四氢吡喃化合物及其酸盐的方法，其化学式为（2）：其中R代表氢原子或烃基，包括在至少选择了一种化合物的存在下，将4-肼基四氢吡喃化合物或其酸盐（化学式（1）中R具有上述相同的含义）进行分解反应，所选择的化合物为Raney镍、贵金属催化剂和金属氧化物，本发明还涉及其合成中间体及其制备方法。
• PROCESS FOR PRODUCTION OF 4-AMINOTETRAHYDROPYRANS AND SALTS THEREOF WITH ACIDS, INTERMEDIATES FOR THE PROCESS, AND PROCESS FOR PRODUCTION THEREOF
  申请人：Ube Industries, Ltd.

  公开号：EP1661894A1

  公开（公告）日：2006-05-31

  The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1) : wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.

  本发明涉及一种制备由式（2）表示的 4-氨基四氢吡喃化合物及其酸盐的工艺： 其中 R 代表氢原子或烃基、 其中 R 代表氢原子或烃基，该工艺包括将式（1）代表的 4-肼基四氢吡喃化合物或其酸 盐： 其中 R 的含义与上述定义相同，在至少一种选自雷尼镍、贵金属催化剂和金属氧化物的化合物存在下进行分解反应，以及其合成中间体和制备方法。
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER
  申请人：Bristol-Myers Squibb Company

  公开号：EP3277670A1

  公开（公告）日：2018-02-07
• INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)
  申请人：Inventisbio Inc.

  公开号：EP3414224A1

  公开（公告）日：2018-12-19