(+/-)1-(5-hydroxyhexyl)-3-methyl-7-methyl-d3-1H-purine-2,6(3H,7H)-dione | 1268605-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (+/-)1-(5-hydroxyhexyl)-3-methyl-7-methyl-d3-1H-purine-2,6(3H,7H)-dione
• 英文别名: 1-(5-Hydroxyhexyl)-3-methyl-7-(trideuteriomethyl)purine-2,6-dione
• CAS: 1268605-96-4
• 化学式: C₁₃H₂₀N₄O₃
• 分子量: 283.303
• InChiKey: NSMXQKNUPPXBRG-BMSJAHLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED XANTHINE DERIVATIVES
  申请人：Tung Roger D.

  公开号：US20110053961A1

  公开（公告）日：2011-03-03

  This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

  本发明涉及一种新型化合物，它们是取代黄嘌呤衍生物及其药学上可接受的盐。例如，本发明涉及一种新型的取代黄嘌呤衍生物，它们是戊酰苄氨基甲基黄嘌呤的衍生物。本发明还提供了包括本发明中的一个或多个化合物和载体的组合物，并且揭示了这些化合物和组合物在治疗戊酰苄氨基甲基黄嘌呤和相关化合物有益的疾病和病症的方法中的应用。
• Substituted xanthine derivatives
  申请人：Concert Pharmaceuticals, Inc.

  公开号：US10335413B2

  公开（公告）日：2019-07-02

  This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

  本发明涉及新型取代黄嘌呤衍生物及其药学上可接受的盐类化合物。例如，本发明涉及新型取代的黄嘌呤衍生物，它们是喷托西林的衍生物。本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所公开的化合物和组合物在治疗喷托西林和相关化合物有益的疾病和病症的方法中的用途。
• US8263601B2
  申请人：——

  公开号：US8263601B2

  公开（公告）日：2012-09-11
• US8987442B2
  申请人：——

  公开号：US8987442B2

  公开（公告）日：2015-03-24
• US8952016B2
  申请人：——

  公开号：US8952016B2

  公开（公告）日：2015-02-10