1-(2-Methylsulfanyl-ethoxymethoxy)-butane | 90951-93-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 1-(2-Methylsulfanyl-ethoxymethoxy)-butane
• 英文别名: 1-(2-Methylsulfanylethoxymethoxy)butane
• CAS: 90951-93-2
• 化学式: C₈H₁₈O₂S
• 分子量: 178.296
• InChiKey: QWNHQGQNLXDQLC-UHFFFAOYSA-N

文献信息

• AMIDITE COMPOUND AND METHOD FOR PRODUCING POLYNUCLEOTIDE USING SAID COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP3786173A1

  公开（公告）日：2021-03-03

  The present invention provides an amidite compound represented by formula (1) which enables a synthesis of RNA with high purity, and the method for preparing a polynucleotide by using the same compound. (In the formula (1), wherein R represents the following formula (wherein Ra and Rb are identical to or different from each other and each represents a methyl group, an ethyl group, or a hydrogen atom, with the proviso that Ra and Rb does not represent a hydrogen atom. n is an integer of 1 to 5), and Ba represents a group containing optionally protected nucleobase structure, and G1 and G2 are identical to or different from each other and each represents a protecting group for a hydroxy group, and G3 are identical to or different from each other and each represents an alkyl group.

  本发明提供了一种由式(1)表示的能合成高纯度RNA的亚酰胺化合物，以及用该化合物制备多核苷酸的方法。(在式(1)中，其中 R 代表下式（其中 Ra 和 Rb 彼此相同或不同，各自代表甲基、乙基或氢原子，但 Ra 和 Rb 不代表氢原子。n 为 1 至 5 的整数），Ba 代表含有可选保护核碱基结构的基团，G1 和 G2 彼此相同或不同，且各自代表羟基的保护基团，G3 彼此相同或不同，且各自代表烷基。