2-((1r,4r)-4-(4-(6-((4-fluoro-3-(trifluoromethoxy)benzyl)carbamoyl)imidazo[2,1-b]thiazol-2-yl)phenyl)cyclohexyl)acetic acid | 1449780-11-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-((1r,4r)-4-(4-(6-((4-fluoro-3-(trifluoromethoxy)benzyl)carbamoyl)imidazo[2,1-b]thiazol-2-yl)phenyl)cyclohexyl)acetic acid
• CAS: 1449780-11-3
• 化学式: C₂₈H₂₅F₄N₃O₄S
• 分子量: 575.584
• InChiKey: WMOYWNPDFMWQAE-SAABIXHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.78
• 重原子数：
  40.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  92.93
• 氢给体数：
  2.0
• 氢受体数：
  6.0

文献信息

• [EN] COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME<br/>[FR] COMPOSÉS COMME INHIBITEURS DE L'ENZYME DIACYLGLYCÉROL O-ACYLTRANSFÉRASE DE TYPE 1
  申请人：KAINOS MEDICINE INC

  公开号：WO2013119040A1

  公开（公告）日：2013-08-15

  The invention provides a novel compound having activity against diacylglycerol O-acyltransferase type 1 (DGAT1); a pharmaceutical composition for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 comprising said compound; a method for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 in an individual comprising administering said compound to the individual in need thereof; and a use of said compound for the manufacture of a medicament for preventing or treating a disease, disorder or condition modulated by DGAT1 inhibition.

  本发明提供了一种对二酰甘油O-酰基转移酶1（DGAT1）具有活性的新化合物；一种用于预防或治疗通过抑制DGAT1调节的疾病，障碍或病症的制剂，包括该化合物；一种预防或治疗个体中通过抑制DGAT1调节的疾病，障碍或病症的方法，包括向需要该化合物的个体施用该化合物；以及用于制造预防或治疗通过DGAT1抑制调节的疾病，障碍或病症的药物的该化合物的用途。
• COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE I ENZYME
  申请人：KAINOS MEDICINE, INC.

  公开号：US20150157611A1

  公开（公告）日：2015-06-11

  The invention provides a novel compound having activity against diacylglycerol O-acyltransferase type 1 (DGAT1); a pharmaceutical composition for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 comprising said compound; a method for preventing or treating a disease, disorder or condition modulated by inhibition of DGAT1 in an individual comprising administering said compound to the individual in need thereof; and a use of said compound for the manufacture of a medicament for preventing or treating a disease, disorder or condition modulated by DGAT1 inhibition.

  本发明提供了一种对二酰甘油O-酰基转移酶类型1（DGAT1）具有活性的新型化合物；一种用于预防或治疗受DGAT1抑制调节的疾病、紊乱或情况的药物组合物，包括该化合物；一种用于预防或治疗受DGAT1抑制调节的疾病、紊乱或情况的方法，包括向需要该化合物的个体施用该化合物；以及用于制造预防或治疗受DGAT1抑制调节的疾病、紊乱或情况的药物的该化合物的用途。
• US9271969B2
  申请人：——

  公开号：US9271969B2

  公开（公告）日：2016-03-01