2'-O-(α-Methoxyaethyl)-uridin | 56673-98-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-O-(α-Methoxyaethyl)-uridin
• 英文别名: O^2'-(1-methoxy-ethyl)-uridine；1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(1-methoxyethoxy)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 56673-98-4
• 化学式: C₁₂H₁₈N₂O₇
• 分子量: 302.284
• InChiKey: XQNYZSBOOZQWGN-JANFQQFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Guanidinium functionalized oligomers and methods
  申请人：——

  公开号：US20030092046A1

  公开（公告）日：2003-05-15

  The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

  本发明提供了寡核苷酸，它们与RNA或DNA的选定序列具有特异性杂交性，其中至少一个核苷酸基团被修饰以包括一种鸟氨酸基团。这些寡核苷酸对于诊断、治疗和调查目的非常有用。
• GUANIDINIUM FUNCTIONALIZED OLIGOMERS AND METHODS
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1206574A2

  公开（公告）日：2002-05-22
• EP1206574A4
  申请人：——

  公开号：EP1206574A4

  公开（公告）日：2002-10-16
• Novel 2'/3'/5'-(R/S)-Serinyl Functionalized Oligonucleotides
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20170044527A1

  公开（公告）日：2017-02-16

  The present invention provides novel chiral serinyl functionalized tethered oligunucleotides i.e. R/S serinyl functionalized tethered oligonucleotides and the process of preparation thereof. Specifically, the present invention provides a modified nucleoside unit containing the R/S serinyl derivative at 2′ of the sugar unit which is introduced in a nucleotide sequence. Also, capping of the oligonucleotides with abasic serinyl derivative to render the nuclease stability to the oligonucleotiedds is also disclosed. The chiral serinyl functionalized tethered oligonucleotides, 2′-O-[R/S-( 2 -amino- 3 -methoxy)propyl] nucleic acids with both ′3- and 5′-ends capped with two units of abasic serine have antisense activity against the miRNA.
• US6534639B1
  申请人：——

  公开号：US6534639B1

  公开（公告）日：2003-03-18