perfluoro(N-butylmorpholine) | 1600-70-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: perfluoro(N-butylmorpholine)
• 英文别名: Octafluor-N-(perfluor-butyl)-morpholin；Perfluor-4-(perfluor-butyl)-morpholin；Perfluor-n-butyl-morpholin；Perfluor-N-n-butylmorpholin；2,2,3,3,5,5,6,6-octafluoro-4-nonafluorobutyl-morpholine；2,2,3,3,5,5,6,6-Octafluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)morpholine
• CAS: 1600-70-0
• 化学式: C₈F₁₇NO
• 分子量: 449.067
• InChiKey: HCUDXGPUYXRLDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  阿哌沙班杂质187 在 氢氟酸 作用下， 反应 10.55h， 以28.8 g的产率得到perfluoro(5-morpholinovaleryl fluoride)
  参考文献：
  名称：

  吗啉代取代的羧酸的几种甲酯和/或乙酯的电化学氟化

  摘要：

  羧酸七甲基和/或乙基酯（CH 2 CH 2 C（O）OET，CH 2 CH 2 CH 2 C（O）OME，CH 2 CH 2 CH 2 C（O）OET，CH （C 2 H ^ 5）C（O）OME，CH（ñ -C 3 ħ 7）C（O）OME，CH 2 CH 2 CH 2 CH 2 C（O）中OEt和CH 2 CH 2 CH 2通道2通道2将具有吗啉代基团的C（O）OEt进行电化学氟化（ECF）。在ECF上，以中等至良好的收率获得了带有全氟吗啉代基团的相应全氟酸氟化物。含有目标全氟吗啉代全氟酸氟​​化物的产率受羧酸的α键裂解以及羧酸烷基的种类的影响（后者提供环化副反应的可能性）。当羧酸烷基的链长为3以上时，吗啉代羧酸的ECF形成全氟氧杂环戊烷作为主要的环化副产物。一种允许环化的方法。当将羧酸的乙基酯进行ECF时，全氟二氧戊环仅以很小的收率作为特定的环化产物获得。描述了所产生的具有

  DOI：

  10.1016/s0022-1139(01)00443-2

文献信息

• CELL ENCAPSULATION DEVICE
  申请人：Boston Scientific Limited A Corporation Of The Country Of Ireland

  公开号：EP3600145A1

  公开（公告）日：2020-02-05
• CELL ENCAPSULATION DEVICE INCLUDING A POROUS TUBE
  申请人：Boston Scientific Scimed Inc.

  公开号：EP3840693A1

  公开（公告）日：2021-06-30
• [EN] CELL ENCAPSULATION DEVICE<br/>[FR] DISPOSITIF D'ENCAPSULATION DE CELLULES
  申请人：BOSTON SCIENT LIMITED A CORPORATION OF THE COUNTRY OF IRELAND

  公开号：WO2018172371A1

  公开（公告）日：2018-09-27

  An implantable device for encapsulating cells includes one or more cell encapsulation layers. Each of the cell encapsulation layers includes a first membrane that is semipermeable, a second membrane that is semipermeable, and a first plurality of weld lines. The second membrane is attached to the first membrane by the first plurality of weld lines. The first membrane, the second membrane, and the first plurality of weld lines define at least one cell channel for encapsulating cells. The cell encapsulation device is configurable between a collapsed configuration and an inflated configuration.
• [EN] CELL ENCAPSULATION DEVICE INCLUDING A POROUS TUBE<br/>[FR] DISPOSITIF D'ENCAPSULATION DE CELLULES COMPRENANT UN TUBE POREUX
  申请人：BOSTON SCIENT SCIMED INC

  公开号：WO2020041446A1

  公开（公告）日：2020-02-27

  A cell encapsulation device for implantation in a body includes one or more cell encapsulation layers, each of the one or more cell encapsulation layers including at least one membrane and a guide tube. The at least one membrane is semipermeable. The least one membrane forms a chamber for encapsulating cells and at least one access port through the at least one membrane. The guide tube extends into the chamber from the at least one access port. The guide tube includes a porous wall along at least a portion of its length. The guide tube is capable of guiding movement of a catheter within the chamber.