3-(3-Oxo-1,2-dihydroisoindol-1-yl)-1-phenylpyrrolidine-2,5-dione | 1393687-05-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(3-Oxo-1,2-dihydroisoindol-1-yl)-1-phenylpyrrolidine-2,5-dione
• 英文别名: 3-(3-oxo-1,2-dihydroisoindol-1-yl)-1-phenylpyrrolidine-2,5-dione
• CAS: 1393687-05-2
• 化学式: C₁₈H₁₄N₂O₃
• 分子量: 306.321
• InChiKey: WHGJTDAXFGGNOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  C₂₀H₁₈N₂O₃ 在 盐酸 、 水 作用下， 反应 24.0h， 以96%的产率得到3-(3-Oxo-1,2-dihydroisoindol-1-yl)-1-phenylpyrrolidine-2,5-dione
  参考文献：
  名称：

  1-乙氧基异吲哚与马来酰亚胺及其衍生物的反应

  摘要：

  We have reported the possibility of conducting the Die Is-Alder [4+2]-cycloaddition reaction with isoindoles that exist predominantly in the isoindoline form, due to the Curtin-Hammet principle. Pursuing our research, we used 1-ethoxyisoindole as the most evident analog of 1-aminoisoindole. This compound is a typical simple isoindole existing chiefly as the isoindoline tautomer. We have studied the reactions of 1-ethoxyisoindoles with maleimide and its derivatives as active dienophiles. In addition, this paper describes the synthesis of a novel compound - tri-(2-methoxycarbonyl)benzylamine.

  DOI：

  10.3987/com-12-12501

文献信息

• Reaction of 1-Ethoxyisoindole with Maleimide and Its Derivatives
  作者：Zoia V. Voitenko、Igor V. Levkov、Stephanie Cassel、Gennady V. Palamarchuk、Oleg V. Shishkin、Svetlana V. Shishkina、Armand Lattes、Isabelle Rico-Lattes

  DOI：10.3987/com-12-12501

  日期：——

  We have reported the possibility of conducting the Die Is-Alder [4+2]-cycloaddition reaction with isoindoles that exist predominantly in the isoindoline form, due to the Curtin-Hammet principle. Pursuing our research, we used 1-ethoxyisoindole as the most evident analog of 1-aminoisoindole. This compound is a typical simple isoindole existing chiefly as the isoindoline tautomer. We have studied the reactions of 1-ethoxyisoindoles with maleimide and its derivatives as active dienophiles. In addition, this paper describes the synthesis of a novel compound - tri-(2-methoxycarbonyl)benzylamine.