4-chloro-N-[(3-chlorophenyl)-[diethoxy(oxido)phosphaniumyl]methyl]aniline | 1371687-06-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-chloro-N-[(3-chlorophenyl)-[diethoxy(oxido)phosphaniumyl]methyl]aniline
• CAS: 1371687-06-7
• 化学式: C₁₇H₂₀Cl₂NO₃P
• 分子量: 388.23
• InChiKey: FYKKIPIPXHKUMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  53.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 3-氯苯甲醛 、 亚磷酸二乙酯 在 choline chloride * 2ZnCl2 作用下， 反应 1.0h， 以83%的产率得到4-chloro-N-[(3-chlorophenyl)-[diethoxy(oxido)phosphaniumyl]methyl]aniline
  参考文献：
  名称：

  Choline chloride·2ZnCl2 ionic liquid: an efficient and reusable catalyst for the solvent free Kabachnik–Fields reaction

  摘要：

  The choline based Zn containing deep eutectic mixture was applied as an efficient and eco-friendly ionic liquid catalyst for the one pot three-component synthesis of alpha-aminophosphonates under solvent-free condition at room temperature. The reactions were completed in short times and products were obtained in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.054

文献信息

• Choline chloride·2ZnCl2 ionic liquid: an efficient and reusable catalyst for the solvent free Kabachnik–Fields reaction
  作者：Shamrao T. Disale、Sandip R. Kale、Sandeep S. Kahandal、Thandankorai G. Srinivasan、Radha V. Jayaram

  DOI：10.1016/j.tetlet.2012.02.054

  日期：2012.5

  The choline based Zn containing deep eutectic mixture was applied as an efficient and eco-friendly ionic liquid catalyst for the one pot three-component synthesis of alpha-aminophosphonates under solvent-free condition at room temperature. The reactions were completed in short times and products were obtained in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.