| 1353015-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1353015-45-8
• 化学式: C₄₅H₅₇N₁₀O₄
• 分子量: 802.012
• InChiKey: QHJFFTPHYBMNTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  59
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  在 水 、 sodium ascorbate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells

  摘要：

  The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (center dot OH) In living cells are described. These probes are highly selective for center dot OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate center dot OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for center dot OH detection.

  DOI：

  10.1021/ol202816m
• 作为产物：
  描述：

  罗丹明B 在 copper(l) iodide 、 sodium azide 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 copper(II) sulfate 、 sodium ascorbate 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 、 叔丁醇 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells

  摘要：

  The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (center dot OH) In living cells are described. These probes are highly selective for center dot OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate center dot OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for center dot OH detection.

  DOI：

  10.1021/ol202816m

文献信息

• New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells
  作者：Nazmiye B. Yapici、Steffen Jockusch、Alberto Moscatelli、Srinivas Rao Mandalapu、Yasuhiro Itagaki、Dallas K. Bates、Sherri Wiseman、K. Michael Gibson、Nicholas J. Turro、Lanrong Bi

  DOI：10.1021/ol202816m

  日期：2012.1.6

  The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (center dot OH) In living cells are described. These probes are highly selective for center dot OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate center dot OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for center dot OH detection.