9,9-Dichloro-9H-fluorene-2,7-dicarboxylic Acid Bis-(3-phenyl-propyl) Ester | 443794-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9,9-Dichloro-9H-fluorene-2,7-dicarboxylic Acid Bis-(3-phenyl-propyl) Ester
• 英文别名: Bis(3-phenylpropyl) 9,9-dichlorofluorene-2,7-dicarboxylate
• CAS: 443794-22-7
• 化学式: C₃₃H₂₈Cl₂O₄
• 分子量: 559.489
• InChiKey: QLJDNVLFZWHWHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
  申请人：——

  公开号：US20020132852A1

  公开（公告）日：2002-09-19

  Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

  描述了对称二取代芳香化合物和含有这种化合物的药物组合物，这些化合物抑制和/或调节聚(ADP核糖)甘油水解酶（也称为PARG）的活性。本发明还涉及使用这些化合物和组合物进行治疗或预防以及通过给予有效量的这些化合物来治疗本文描述的疾病和紊乱的方法。
• [EN] SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE<br/>[FR] COMPOSES AROMATIQUES SYMETRIQUEMENT DISUBSTITUES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT D'INHIBER LA POLY (ADP-RIBOSE) GLYCOHYDROLASE, ET PROCEDES D'UTILISATION ASSOCIES
  申请人：GUILFORD PHARM INC

  公开号：WO2002057211A1

  公开（公告）日：2002-07-25

  Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

  本文描述了对称二取代芳香族化合物和含有此类化合物的制药组合物，这些化合物可以抑制和/或调节聚(ADP-核糖)酰基水解酶的活性，也称为PARG。本发明还涉及使用这些化合物和组合物的治疗或预防用途，以及通过给予有效量的这些化合物来治疗本文所述的疾病和障碍的方法。
• SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1360167A1

  公开（公告）日：2003-11-12
• US6635786B2
  申请人：——

  公开号：US6635786B2

  公开（公告）日：2003-10-21