N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(3-phenylpropyl)-L-cysteine | 625845-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(3-phenylpropyl)-L-cysteine
• 英文别名: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-phenylpropylsulfanyl)propanoic acid
• CAS: 625845-47-8
• 化学式: C₂₇H₂₇NO₄S
• 分子量: 461.582
• InChiKey: YQESXHMDEKVAOD-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS<br/>[FR] DERIVES D'ETHER 8-AZABICYCLO[3.2.1]OCTANE ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DE RECEPTEUR DE NEUROKININE
  申请人：MERCK SHARP & DOHME

  公开号：WO2004031185A1

  公开（公告）日：2004-04-15

  The present invention relates compounds of the formula (I) : wherein X represents hydrogen, C1-4alkyl optionally substituted by a hydroxy, methoxy or benzyloxy group, or CO2(C1-2alkyl); Z is -CR9R10CH2- or -CH2CR9R10-; and R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.

  本发明涉及以下式(I)的化合物：其中X代表氢，C1-4烷基，可选择地被羟基，甲氧基或苄氧基取代，或CO2(C1-2烷基)；Z为-CR9R10CH2-或-CH2CR9R10-；而R1、R2、R3、R4、R5和R6如本文所定义。这些化合物在治疗或预防抑郁症、焦虑、疼痛、炎症、偏头痛、呕吐或带状疱疹后神经痛方面具有特殊用途。
• Peptide compounds and their use as protease substrates
  申请人：——

  公开号：US20040018561A1

  公开（公告）日：2004-01-29

  This invention is directed generally to peptide compounds and salts, and particularly to peptide compounds and salts that are useful as protease substrates, such as matrix metalloprotease (“MMP”) substrates. This invention also is directed to methods for making such compounds and salts, as well as amino acids that may, for example, be used in such methods. This invention is further directed to methods for using such compounds and salts to, for example, evaluate the effectiveness of potential protease inhibitors and to detect or monitor a disease associated with protease activity.

  该发明通常涉及肽化合物和盐，特别是肽化合物和盐，它们可作为蛋白酶底物，例如基质金属蛋白酶（“MMP”）底物。该发明还涉及制备这类化合物和盐的方法，以及可能用于这类方法中的氨基酸。该发明还进一步涉及使用这类化合物和盐的方法，例如用于评估潜在的蛋白酶抑制剂的有效性，以及检测或监测与蛋白酶活性相关的疾病。
• PEPTIDE COMPOUNDS AND THEIR USE AS PROTEASE SUBSTRATES
  申请人：Pharmacia Corporation

  公开号：EP1504094A2

  公开（公告）日：2005-02-09
• 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1551832A1

  公开（公告）日：2005-07-13
• [EN] PEPTIDE COMPOUNDS AND THEIR USE AS PROTEASE SUBSTRATES<br/>[FR] COMPOSES PEPTIDIQUES ET LEUR UTILISATION COMME SUBSTRATS DE PROTEASES
  申请人：PHARMACIA CORP

  公开号：WO2003095475A2

  公开（公告）日：2003-11-20

  This invention is directed generally to peptide compounds and salts, and particularly to peptide compounds and salts that are useful as protease substrates, such as matrix metalloprotease (“MMP”) substrates. This invention also is directed to methods for making such compounds and salts, as well as amino acids that may, for example, be used in such methods. This invention is further directed to methods for using such compounds and salts to, for example, evaluate the effectiveness of potential protease inhibitors and to detect or monitor a disease associated with protease activity.