Hydroxamic | 1160626-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Hydroxamic
• 英文别名: 2-hydroxy-3,3-dimethyl-7-nitro-4H-isoquinolin-1-one
• CAS: 1160626-68-5
• 化学式: C₁₁H₁₂N₂O₄
• 分子量: 236.227
• InChiKey: NEAQRZUHTPSBBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,3-dimethyl-7-nitro-3,4-dihydroisoquinoline 在 甲烷磺酸 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 30.0h， 生成 3,3-dimethyl-7-nitro-2-oxido-4H-isoquinolin-2-ium 、 Hydroxamic
  参考文献：
  名称：

  Synthesis and Reactivity Study of Two New Dihydroisoquinoline-Derived Oxaziridines

  摘要：

  [image omitted] The N-alkyl oxaziridines may be used as reagents for the oxidation of sulfides in acid-promoted reactions. The present work describes the behavior of two newly synthesized dihydroisoquinoline-derived oxaziridines with respect to methanesulfonic acid. An isomerization reaction was observed in the absence of sulfide.

  DOI：

  10.1080/00397911.2010.487175

文献信息

• Unexpected Formation of O-Acylhydroxamate from the Oxidation of a Dihydroisoquinoline Imine
  作者：Hassen Ben Saleh、Majed Kammoun、Besma Hamdi、Mohamed Damak

  DOI：10.1080/00397911.2011.580882

  日期：2012.11.15

  The reaction of 3,3-dimethyl-7-nitro-3,4-dihydroisoquinoline 1 with m-chloroperbenzoic acid (m-CPBA) mainly yielded oxaziridine and nitrone, with their selectivities being dependent on the solvents. The reaction with 2.5 equivalents of m-CPBA gave small amounts of oxaziridines and hydroxamic acids as well as isolated O-acylhydroxamate compounds.