7-({3-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-1-yl}carbonyl)imidazo[1,2-α]pyridine | 1238877-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 7-({3-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidin-1-yl}carbonyl)imidazo[1,2-α]pyridine
• 英文别名: (4-Cyclobutyl-1,4-diazepan-1-yl)-[1-(imidazo[1,2-a]pyridine-7-carbonyl)azetidin-3-yl]methanone
• CAS: 1238877-02-5
• 化学式: C₂₁H₂₇N₅O₂
• 分子量: 381.478
• InChiKey: OFRMZANRCBZEIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS<br/>[FR] AZÉTIDINES EN TANT QU'ANTAGONISTES DES RÉCEPTEURS H3 DE L'HISTAMINE
  申请人：EVOTEC NEUROSCIENCES GMBH

  公开号：WO2010086403A1

  公开（公告）日：2010-08-05

  The invention relates to compounds of formula (I), wherein R, R1, m, n and X1to X3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

  该发明涉及式(I)的化合物，其中R、R1、m、n和X1至X3的含义如描述和权利要求中所述。所述化合物可用作组胺H3受体拮抗剂。该发明还涉及制药组合物，以及这些化合物的制备、生产和用作药物的方法。
• AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS
  申请人：Davenport Adam James

  公开号：US20120040952A1

  公开（公告）日：2012-02-16

  The invention relates to compounds of formula (I), wherein R, R 1 , m, n and X 1 to X 3 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

  该发明涉及式（I）的化合物，其中R、R1、m、n和X1至X3的含义如描述和权利要求中所述。所述化合物可用作组胺H3受体拮抗剂。该发明还涉及制药组合物、制备此类化合物以及作为药物的生产和使用。
• US8912176B2
  申请人：——

  公开号：US8912176B2

  公开（公告）日：2014-12-16