(E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-4-methoxyphenol | 1350842-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-4-methoxyphenol
• CAS: 1350842-47-5
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: CHRNXRHQYRPYQQ-NTUHNPAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  62.05
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-羟基-5-甲氧基苯甲醛 、 2-氨基-2-甲基-1-丙醇 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以94%的产率得到(E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-4-methoxyphenol
  参考文献：
  名称：

  Racemization of secondary alcohols catalyzed by ruthenium: application to chemoenzymatic dynamic resolution

  摘要：

  In this paper, we have shown that the [RuCl2(p-cymene)](2) complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2(p-cymene)](2)/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out dynamic kinetic resolution experiments on rac-phenylethanol. This led us to identify the best conditions for effective DKR, which was then applied to various secondary benzylic and aliphatic alcohols. It was thus possible to obtain (R)-1-cyclohexylethyl acetate from rac-1-cyclohexylethanol in quantitative conversion and with high enantioselectivity (98%). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.10.007
• 作为试剂：
  描述：

  (S)-(-)-1-苯乙醇 在 2,2,6,6-四甲基哌啶氧化物 、 二氯(p-甲基异丙苯)钌(II) 二聚体 、 (E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-4-methoxyphenol 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 (R)-(+)-1-苯基乙醇
  参考文献：
  名称：

  Racemization of secondary alcohols catalyzed by ruthenium: application to chemoenzymatic dynamic resolution

  摘要：

  In this paper, we have shown that the [RuCl2(p-cymene)](2) complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2(p-cymene)](2)/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out dynamic kinetic resolution experiments on rac-phenylethanol. This led us to identify the best conditions for effective DKR, which was then applied to various secondary benzylic and aliphatic alcohols. It was thus possible to obtain (R)-1-cyclohexylethyl acetate from rac-1-cyclohexylethanol in quantitative conversion and with high enantioselectivity (98%). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.10.007

文献信息

• METHOD FOR PRODUCING SULFOXIDE DERIVATIVE
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：EP3424903A1

  公开（公告）日：2019-01-09

  [Problem] To provide an industrially preferred method for producing a sulfoxide derivative. [Solution] A method for producing a sulfoxide derivative represented by general formula (1), the method being characterized in that a sulfide derivative represented by general formula (2) is reacted with an oxidizing agent in the presence of a catalyst that is a metal-ligand complex containing a metal compound and, as a ligand, a compound represented by general formula (3), and in the presence of a benzoic acid compound represented by general formula (4). Selected drawing: None

  问题 提供一种生产亚砜衍生物的工业优选方法。 [解决方案］ 一种生产由通式（1）表示的亚砜衍生物的方法、 该方法的特征在于，由通式（2）表示的亚砜衍生物 在催化剂存在下与氧化剂反应，催化剂是一种金属-配体复合物，其中含有一种金属化合物和作为配体的通式（3）所代表的化合物、 和通式（4）代表的苯甲酸化合物的存在下与氧化剂反应。 选定的图纸：无
• Method for producing sulfoxide derivative
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US10577313B2

  公开（公告）日：2020-03-03

  A method for producing a sulfoxide derivative represented by general formula (1), the method being characterized in that a sulfide derivative represented by general formula (2) is reacted with an oxidizing agent in the presence of a catalyst that is a metal-ligand complex containing a metal compound and, as a ligand, a compound represented by general formula (3), and in the presence of a benzoic acid compound represented by general formula (4)

  一种生产通式（1）所代表的亚砜衍生物的方法、 该方法的特征在于，由通式（2）表示的硫醚衍生物 在催化剂存在下与氧化剂反应，催化剂是一种金属-配体络合物，其中包含一种金属化合物和作为配体的通式 (3) 所代表的化合物、 和通式 (4) 所代表的苯甲酸化合物的存在下