methyl (S)-3-O-dimethoxytrityl-2-O-((E)-3-phenyl-2-propen-1-yl)-glycerate | 402856-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: methyl (S)-3-O-dimethoxytrityl-2-O-((E)-3-phenyl-2-propen-1-yl)-glycerate
• 英文别名: methyl (2S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[(E)-3-phenylprop-2-enoxy]propanoate
• CAS: 402856-14-8
• 化学式: C₃₄H₃₄O₆
• 分子量: 538.64
• InChiKey: OXYMKWBSGPDNSE-KVWOZJIWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  40
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl (S)-3-O-dimethoxytrityl-2-O-((E)-3-phenyl-2-propen-1-yl)-glycerate 在 溶剂黄146 作用下， 反应 3.0h， 以88%的产率得到methyl (S)-2-O-((E)-3-phenyl-2-propen-1-yl)-glycerate
  参考文献：
  名称：

  A cross metathesis-based synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins

  摘要：

  Conditions are reported which allow to convert optically active methyl glycerate to the 2-O-allyl derivative without racemization. Cross metathesis reactions then lead to analogues of the 2-O-alkyl glycerate part of the moenomycin antibiotics. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00988-7
• 作为产物：
  描述：

  methyl (S)-3-O-dimethoxytrityl-glycerate 在 Grubbs catalyst first generation silver(l) oxide 作用下， 以 乙醚 、 1,2-二氯乙烷 为溶剂， 反应 72.0h， 生成 methyl (S)-3-O-dimethoxytrityl-2-O-((E)-3-phenyl-2-propen-1-yl)-glycerate
  参考文献：
  名称：

  A cross metathesis-based synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins

  摘要：

  Conditions are reported which allow to convert optically active methyl glycerate to the 2-O-allyl derivative without racemization. Cross metathesis reactions then lead to analogues of the 2-O-alkyl glycerate part of the moenomycin antibiotics. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00988-7

文献信息

• A cross metathesis-based synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins
  作者：Uwe Eichelberger、Madina Mansourova、Lothar Hennig、Matthias Findeisen、Sabine Giesa、Dietrich Müller、Peter Welzel

  DOI：10.1016/s0040-4020(01)00988-7

  日期：2001.11

  Conditions are reported which allow to convert optically active methyl glycerate to the 2-O-allyl derivative without racemization. Cross metathesis reactions then lead to analogues of the 2-O-alkyl glycerate part of the moenomycin antibiotics. (C) 2001 Elsevier Science Ltd. All rights reserved.