methyl (S)-3-O-dimethoxytrityl-glycerate | 132446-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: methyl (S)-3-O-dimethoxytrityl-glycerate
• 英文别名: 3-O-dimethoxytrityl-(S)-glyceric acid methyl ester；methyl (2S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-hydroxypropanoate
• CAS: 132446-39-0
• 化学式: C₂₅H₂₆O₆
• 分子量: 422.478
• InChiKey: KJWSWALGCINKOP-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.55
• 重原子数：
  31.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  74.22
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  methyl (S)-3-O-dimethoxytrityl-glycerate 在 Grubbs catalyst first generation silver(l) oxide 作用下， 以 乙醚 、 1,2-二氯乙烷 为溶剂， 反应 72.0h， 生成 methyl (S)-3-O-dimethoxytrityl-2-O-((E)-2-heptadecen-1-yl)-glycerate
  参考文献：
  名称：

  A cross metathesis-based synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins

  摘要：

  Conditions are reported which allow to convert optically active methyl glycerate to the 2-O-allyl derivative without racemization. Cross metathesis reactions then lead to analogues of the 2-O-alkyl glycerate part of the moenomycin antibiotics. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00988-7
• 作为产物：
  描述：

  （s）-2,3-二羟基丙酸甲酯 、 4,4'-双甲氧基三苯甲基氯 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 methyl (S)-3-O-dimethoxytrityl-glycerate
  参考文献：
  名称：

  [EN] SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES
  [FR] SYNTHÈSE DE PHOSPHORAMIDITES À BASE DE POLYOLS ISOMÉRIQUEMENT PURS

  摘要：

  The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.

  公开号：

  WO2023186842A1

文献信息

• Syntheses of heparin - like pentamers containing “opened” uronic acid moieties
  作者：H. Lucas、J.E.M. Hasten、Th.G. van Dinther、D.G. Meuleman、S.F. van Aelst、C.A.A. van Boeckel

  DOI：10.1016/s0040-4020(01)81477-0

  日期：——
• [EN] SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES<br/>[FR] SYNTHÈSE DE PHOSPHORAMIDITES À BASE DE POLYOLS ISOMÉRIQUEMENT PURS
  申请人：[en]F. HOFFMANN-LA ROCHE AG

  公开号：WO2023186842A1

  公开（公告）日：2023-10-05

  The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.
• A cross metathesis-based synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins
  作者：Uwe Eichelberger、Madina Mansourova、Lothar Hennig、Matthias Findeisen、Sabine Giesa、Dietrich Müller、Peter Welzel

  DOI：10.1016/s0040-4020(01)00988-7

  日期：2001.11

  Conditions are reported which allow to convert optically active methyl glycerate to the 2-O-allyl derivative without racemization. Cross metathesis reactions then lead to analogues of the 2-O-alkyl glycerate part of the moenomycin antibiotics. (C) 2001 Elsevier Science Ltd. All rights reserved.