His-His-Ile-Tyr-Leu-Gly-Ala-Val-Asn-Tyr-Ile-Tyr-NH2 | 2040964-58-5

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: His-His-Ile-Tyr-Leu-Gly-Ala-Val-Asn-Tyr-Ile-Tyr-NH2
• 英文别名: (2S)-N-[(2S)-1-[[(2S,3S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]butanediamide
• CAS: 2040964-58-5
• 化学式: C₇₁H₁₀₀N₁₈O₁₆
• 分子量: 1461.7
• InChiKey: MDQMJABKOUZYGG-QZJYLVOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  105
• 可旋转键数：
  42
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  550
• 氢给体数：
  19
• 氢受体数：
  19

文献信息

• PEPTIDE COMPOSITIONS AND METHODS OF USE
  申请人：ONL Therapeutics, Inc.

  公开号：EP3288379B1

  公开（公告）日：2021-11-03
• COMPOSITIONS AND METHODS OF FAS INHIBITION
  申请人：ONL THERAPEUTICS, INC.

  公开号：US20190201500A1

  公开（公告）日：2019-07-04

  Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis. Also, described are compositions and methods for preventing, treating or ameliorating an inflammation-mediated and/or complement-mediated disease or condition in a subject comprising administering to the subject a Fas inhibitor, its derivative, a pharmaceutically acceptable salt thereof, of a gene therapy encoding the Fas inhibitor in an amount effective to inhibit Fas signaling.
• [EN] PEPTIDE COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS DE PEPTIDES ET LEURS MÉTHODES D'UTILISATION
  申请人：ONL THERAPEUTICS INC

  公开号：WO2016178993A1

  公开（公告）日：2016-11-10

  Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.