3,6-dioxo-23,24-dinor-5β-cholanoic acid-(22)-methyl ester | 121916-96-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,6-dioxo-23,24-dinor-5β-cholanoic acid-(22)-methyl ester
• 英文别名: 3.6-Dioxo-20β_F-methyl-5β-pregnansaeure-(21)-methylester；3,6-Dioxo-23,24-dinor-5β-cholansaeure-(22)-methylester；methyl (2S)-2-[(5R,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3,6-dioxo-2,4,5,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate
• CAS: 121916-96-9
• 化学式: C₂₃H₃₄O₄
• 分子量: 374.521
• InChiKey: RDDUZOVSWADKSS-ILZLXJEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,6-dioxo-23,24-dinor-5β-cholanoic acid-(22)-methyl ester 、 甲醇 、 盐酸 生成 methyl (20S)-3,6-dioxo-5α-pregnane-20-carboxylate
  参考文献：
  名称：

  ZHOU, WEI-SHAN;JIANG, LI-ZHONG;TIAN, WEI-SHENG;ZHAO, XU-YANG;ZHENG, HU, XUASYUEH SYUEHBAO, 46,(1988) N2, S. 1212-1218

  摘要：

  DOI：
• 作为产物：
  描述：

  3α,6α-dihydroxy-23,24-dinor-5β-cholanoic acid-(22) 在 chromium(VI) oxide 、 乙醚 、 溶剂黄146 作用下， 生成 3,6-dioxo-23,24-dinor-5β-cholanoic acid-(22)-methyl ester
  参考文献：
  名称：

  Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats

  摘要：

  Present experiments were carried out in 23-day-old female rats to analyze the interaction between excitatory amino acids (EAAs) and gamma-aminobutyric acid (GABA) in the control of gonadotropin and GH secretion. For this purpose, serum concentrations of LH, FSH and GH were measured after injection of different agonists of EAA receptor subtypes [N-methyl-D-aspartate (NMDA); kainic acid (KA), +/--alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)], antagonists of GABA receptors (bicuculline, phaclofen) or the combined administration of both types of drugs. The results obtained indicated that: 1) GABA has a minor physiological role in the control of LH and GH secretion, since neither LH nor GH serum concentrations changed after administration of bicuculline (antagonist of GABA(A) receptors) or phaclofen (antagonist of GABA(B) receptors); 2) GABA has a sex-specific physiological role in the control of FSH secretion in female rats, in which FSH secretion increases after phaclofen administration; 3) GH secretion was enhanced after administration of NMDA, KA and AMPA, while LH increased only after activation of NMDA receptors; 4) the stimulatory effect of NMDA on LH secretion was counteracted by administration of phaclofen; and 5) bicuculline and phaclofen reduced the ability of NMDA and AMPA to stimulate GH secretion. In conclusion, present experiments evidenced a physiological role of GABA, mediated by GABA(B) receptors, in the control of FSH secretion and a cross-talk between excitatory and inhibitory amino acids in the control of anterior pituitary secretion. (C) 2002, Editrice Kurtis.

  DOI：

  10.1007/bf03343970

文献信息

• Degradation of Hyodesoxycholic Acid
  作者：Robert Bruce Moffett、James E. Stafford、Jacob Linsk、Willard M. Hoehn

  DOI：10.1021/ja01213a052

  日期：1946.9