2-azaniumylethyl (2R)-3-{[(1Z)-hexadec-1-en-1-yl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl phosphate | 65289-02-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-azaniumylethyl (2R)-3-{[(1Z)-hexadec-1-en-1-yl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl phosphate
• 英文别名: 2-azaniumylethyl [(2R)-3-[(Z)-hexadec-1-enoxy]-2-[(Z)-octadec-9-enoyl]oxypropyl] phosphate
• CAS: 65289-02-3
• 化学式: C39H76NO7P
• 分子量: 702.0
• InChiKey: ZVVYJAAMWXATNY-PRWZWGSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  48
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders
  申请人：Harats Dror

  公开号：US20070099868A1

  公开（公告）日：2007-05-03

  Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

  本发明提供了一种新型合成氧化脂质及利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。
• NANOPARTICLE-BASED DELIVERY SYSTEM WITH OXIDIZED PHOSPHOLIPIDS AS TARGETING LIGANDS FOR THE PREVENTION, DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS
  申请人：WANG Shu

  公开号：US20140287024A1

  公开（公告）日：2014-09-25

  Disclosed are nanoparticle-based medicine/nutrient delivery system that are coated or incorporated with oxidized phospholipids as targeting ligands. Such delivery systems can specifically target macrophages, which are determinant cells in the aortic wall for atherosclerotic lesion development, to significantly increase bioavailability and specificity for the prevention, diagnosis and treatment of atherosclerosis.

  揭示了一种基于纳米颗粒的医药/营养素传递系统，其涂有或包含氧化磷脂作为靶向配体。这样的传递系统可以特异性地靶向巨噬细胞，它们是动脉壁上动脉粥样硬化病变发展的决定性细胞，从而显着增加生物利用度和特异性，用于预防、诊断和治疗动脉粥样硬化。
• US7973023B2
  申请人：——

  公开号：US7973023B2

  公开（公告）日：2011-07-05