2-(morpholin-4-yl)-3-phenylquinazolin-4(3H)-one | 741-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(morpholin-4-yl)-3-phenylquinazolin-4(3H)-one
• 英文别名: 2-morpholino-3-phenylquinazolin-4(3H)-one；2-morpholin-4-yl-3-phenyl-3H-quinazolin-4-one；2-Morpholin-4-yl-3-phenylquinazolin-4-one
• CAS: 741-76-4
• 化学式: C₁₈H₁₇N₃O₂
• 分子量: 307.352
• InChiKey: HXKFZBDETFUOLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-苯基-2,4(1H,3H)-喹唑啉二酮 在 五氯化磷 、 三氯氧磷 作用下， 以 苯 为溶剂， 反应 12.0h， 生成 2-(morpholin-4-yl)-3-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Talukdar, P. B.; Sengupta, S. K.; Datta, A. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 8, p. 638 - 640

  摘要：

  DOI：

文献信息

• A Facile Synthesis of 2-Mino-3H-Quinazolin-4-Ones with Tandem Aza-Wittig Reaction
  作者：Ming-Wu Ding、Gui-Ping Zeng、Tian-Jie Wu

  DOI：10.1080/00397910008087195

  日期：2000.4.1

  Abstract 2-Amino-3H-quinazolin-4-ones 8 were prepared from tandem aza-Wittig reaction of iminophosphorane 5 with aromatic isocyanate and nucleaphilic reagent HY in mild condition.

  摘要 2-氨基-3H-喹唑啉-4-酮8 由亚氨基正膦5 与芳香异氰酸酯和亲核试剂HY 在温和条件下进行串联氮杂-Wittig 反应制备。
• Solid-Phase Synthesis of 3<i>H</i>-Quinazolin-4-ones Based on an Aza Wittig-Mediated annulation Strategy
  作者：José M. Villalgordo、Daniel Obrecht、Alexander Chucholowsky

  DOI：10.1055/s-1998-1971

  日期：1998.12

  Aza Wittig-mediated annulation provides a highly efficient and straightforward strategy for the parallel synthesis of 3H-quinazolin-4-ones on solid support. The products were recovered in good yields and exhibited excellent purities.

  Aza Wittig介导的环化提供了一种高效且直接的策略，用于在固相上并行合成3H-喹唑啉-4-酮。产品以良好的产率回收，并展现了优异的纯度。
• Tandem Palladium-Catalyzed Addition/Cyclocarbonylation: An Efficient Synthesis of 2-Heteroquinazolin-4(<i>3H</i>)-ones
  作者：Fanlong Zeng、Howard Alper

  DOI：10.1021/ol902924x

  日期：2010.3.19

  A highly practical and efficient method for the synthesis of 2-heteroquinazolin-4(3H)-ones has been developed by a palladium-catalyzed tandem reaction. Under mild reaction conditions (80 degrees C, 100 psi), a wide variety of 2-heteroquinazolin-4(3H)-ones were obtained in good to excellent yields.
• Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation
  作者：Bryan Roberts、David Liptrot、Tim Luker、Michael J. Stocks、Catherine Barber、Nicola Webb、Robert Dods、Barrie Martin

  DOI：10.1016/j.tetlet.2011.05.052

  日期：2011.7

  A new, efficient and practical synthesis of quinazolin-4(3H)-ones is reported via molybdenum-mediated cyclocarbonylation using microwave irradiation. These methods allow access to a wide range of quinazolin-4(314)-ones in reasonable yields without the need for gaseous carbon monoxide and palladium catalysts. A range of reactions illustrating the wide scope of this chemistry was carried out and all proceeded in reasonable yields. (C) 2011 Elsevier Ltd. All rights reserved.
• Pesson,M.; Richer,D., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1965, vol. 260, p. 603 - 605
  作者：Pesson,M.、Richer,D.

  DOI：——

  日期：——