5-Ethoxy-3,4-bis-trimethylsilanyl-3H-furan-2-one | 211871-18-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-Ethoxy-3,4-bis-trimethylsilanyl-3H-furan-2-one
• 英文别名: 5-Ethoxy-3,4-bis(trimethylsilyl)-2(3H)-furanone；5-ethoxy-3,4-bis(trimethylsilyl)-3H-furan-2-one
• CAS: 211871-18-0
• 化学式: C₁₂H₂₄O₃Si₂
• 分子量: 272.492
• InChiKey: YUXRTYIPXLIPIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙醇 、 bis(trimethylsilyl)-1,2-bisketene 在 salicylic aldehyde (S)-1-phenylethylamine Schiff base copper(II) 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以95%的产率得到5-Ethoxy-3,4-bis-trimethylsilanyl-3H-furan-2-one
  参考文献：
  名称：

  A Novel Copper Chelate Catalyzed Ring Closure Reaction of 1,2-Bisketenes with Alcohols To Give 5-Alkoxy-2,3-dihydrofuran-2-ones

  摘要：

  Copper complexes with distorted tetrahedral structure in solution catalyze regioselectively the cyclization of 1,2-bisketenes with alcohols to give 5-alkoxy-2,3-dihydrofuran-2-ones in very high yields (shown on the right). It seems remarkable that these new compounds could remain undiscovered despite having structural similarities with a great number of well-investigated and biologically active butenolides.

  DOI：

  10.1002/(sici)1521-3773(19980619)37:11<1540::aid-anie1540>3.0.co;2-x

文献信息

• A Novel Copper Chelate Catalyzed Ring Closure Reaction of 1,2-Bisketenes with Alcohols To Give 5-Alkoxy-2,3-dihydrofuran-2-ones
  作者：Michael M. Dejmek、Rüdiger Selke

  DOI：10.1002/(sici)1521-3773(19980619)37:11<1540::aid-anie1540>3.0.co;2-x

  日期：1998.6.19

  Copper complexes with distorted tetrahedral structure in solution catalyze regioselectively the cyclization of 1,2-bisketenes with alcohols to give 5-alkoxy-2,3-dihydrofuran-2-ones in very high yields (shown on the right). It seems remarkable that these new compounds could remain undiscovered despite having structural similarities with a great number of well-investigated and biologically active butenolides.