2-(7-methyl-imidazo-[1,2-a]pyridin-3-yl)-ethyl-bisphosphonic acid | 1219126-91-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(7-methyl-imidazo-[1,2-a]pyridin-3-yl)-ethyl-bisphosphonic acid
• 英文别名: 2-(7-methyl-imidazo-[1,2-a]pyridin-3-yl)-ethyl-1,1-bisphosphonic acid；[2-(7-Methylimidazo[1,2-a]pyridin-3-yl)-1-phosphonoethyl]phosphonic acid
• CAS: 1219126-91-6
• 化学式: C₁₀H₁₄N₂O₆P₂
• 分子量: 320.178
• InChiKey: AYZPSNGXUXQPQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• MEVALONIC ACID PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：Tsinghua University

  公开号：EP3698797A1

  公开（公告）日：2020-08-26

  Provided in the present invention is the use of a mevalonic acid pathway inhibitor in the preparation of a drug for treating and/or preventing tumours, inducing immunogenic death of tumour cells, inducing immune responses and activating T cells or DC cells to directly promote host immunity. Also provided in the present invention is a pharmaceutical composition comprising the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and a combination of the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and/or the radiotherapy.

  本发明提供了一种甲羟戊酸通路抑制剂在制备治疗和/或预防肿瘤药物中的用途，诱导肿瘤细胞的免疫原性死亡，诱导免疫反应，激活T细胞或DC细胞以直接促进宿主免疫。本发明还提供了一种药物组合物，包括甲羟戊酸途径抑制剂和抗肿瘤药物（例如，免疫检查点抑制剂和任何可导致产生新抗原的药物），以及甲羟戊酸途径抑制剂和抗肿瘤药物（例如，免疫检查点抑制剂和任何可导致产生新抗原的药物）和/或放疗的组合。
• IMIDAZO[1,2- ALPHA]PYRIDINYL BISPHOSPHONATES
  申请人：Isis Innovation Ltd

  公开号：EP2350076B1

  公开（公告）日：2013-08-21