ra-rU | 65676-45-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （3'->5'）-二核苷酸和类似物
• 英文名称: ra-rU
• 英文别名: d-Apt；5-methyl-uridylyl-(5'->3')-adenosine
• CAS: 65676-45-1
• 化学式: C₂₀H₂₆N₇O₁₂P
• 分子量: 587.44
• InChiKey: XJHHAKJEAXOWGC-PJADBFDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.36
• 重原子数：
  40.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  279.62
• 氢给体数：
  7.0
• 氢受体数：
  17.0

反应信息

• 作为产物：
  描述：

  rA(Bz, TBS)-rU(TBS)-Kc 在 四丁基氟化铵 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 ra-rU
  参考文献：
  名称：

  [EN] PSEUDO SOLID PHASE PROTECTING GROUP AND METHODS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES AND OLIGONUCLEOTIDE CONJUGATES
  [FR] GROUPE DE PROTECTION DE PSEUDO-PHASE SOLIDE ET PROCÉDÉS DE SYNTHÈSE D'OLIGONUCLÉOTIDES ET DE CONJUGUÉS D'OLIGONUCLÉOTIDES

  摘要：

  A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the point of attachment to an oxygen atom of a hydroxyl moiety of the nucleoside, the nucleotide, the oligonucleotide, or of the conjugate of a nucleoside, a nucleotide or an oligonucleotide to be protected; c is 0 or 1; a is an integer of 1 to 12; R3 is H; R5 is O-R6 or H, where R6 is a C8-C40 aliphatic hydrocarbon group; each of R4 is independently O-R6, where R6 is at each occurrence independently a C8-C40 aliphatic hydrocarbon group; b is 1 to 3; with the proviso that if b is 1, at least one of R3 and R5 is not H; and with the further proviso that the sum of all carbon atoms contained in the R3, R4, and R5 moieties present is larger than 23 and smaller than 200.

  公开号：

  WO2022214692A1