N-(2,5-Dimethyl-1H-pyrrol-1-yl)-4-morpholino-1-phthalazineamine | 75841-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(2,5-Dimethyl-1H-pyrrol-1-yl)-4-morpholino-1-phthalazineamine
• 英文别名: N-(2,5-dimethylpyrrol-1-yl)-4-morpholin-4-ylphthalazin-1-amine
• CAS: 75841-86-0
• 化学式: C₁₈H₂₁N₅O
• 分子量: 323.398
• InChiKey: KCKXVOSDHADXST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (4-Morpholin-4-yl-phthalazin-1-yl)-hydrazine 、 2,5-己二酮 以 溶剂黄146 为溶剂， 反应 3.0h， 生成 N-(2,5-Dimethyl-1H-pyrrol-1-yl)-4-morpholino-1-phthalazineamine
  参考文献：
  名称：

  N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents

  摘要：

  新的吡咯基-3-吡啶嗪胺类化合物，在位置6上进一步具有氨基取代基。这些化合物可用作降压药物，并可从6-氨基取代-3-肼基吡啶嗪和β-二羰基化合物制备。本发明还声明了将新化合物用作降压药物以及含有新化合物作为活性成分的组合物的用途。

  公开号：

  US04247551A1

文献信息

• Antihypertensives. N-1H-Pyrrol-1-yl-3-pyridazinamines
  作者：Elvio Bellasio、Ambrogio Campi、Nunzio Di Mola、Emiliana Baldoli

  DOI：10.1021/jm00374a024

  日期：1984.8

  The hypothesis that the side effects of hydralazine, such as mutagenicity and lupus erythematosus like syndrome, might be due to the NHNH2 group prompted us to incorporate part of this moiety into a pyrrole ring. Therefore, we prepared a series of N-1H-pyrrol-1-yl-3-pyridazinamines and a limited number of N-1H-pyrrol-1-yl-1-phthalazinamines by reaction of 3-hydrazinopyridazines and 1-hydrazinophthalazines with gamma-diketones. Most of these compounds, especially in the pyridazine series, showed moderate to strong antihypertensive activity in spontaneously hypertensive rats. The decrease in blood pressure generally had a slow onset after either oral or intravenous administration. N-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine hydrochloride (30) (MDL 899) showed no mutagenic activity in several tests and is now in clinical trials in patients.
• 6-Amino substituted N-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them
  申请人：GRUPPO LEPETIT S.P.A.

  公开号：EP0009655B1

  公开（公告）日：1983-05-11
• US4247551A
  申请人：——

  公开号：US4247551A

  公开（公告）日：1981-01-27