[Bis-(2-hydroxyethyl)-amino]-methylenmalononitril | 16956-53-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [Bis-(2-hydroxyethyl)-amino]-methylenmalononitril
• 英文别名: {[Bis(2-hydroxyethyl)amino]methylidene}propanedinitrile；2-[[bis(2-hydroxyethyl)amino]methylidene]propanedinitrile
• CAS: 16956-53-9
• 化学式: C₈H₁₁N₃O₂
• 分子量: 181.194
• InChiKey: OMKRYUHVPHQNPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  91.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二乙醇胺 、 2-(Ethoxyamino-methylene)-malononitrile 以 乙醇 为溶剂， 生成 [Bis-(2-hydroxyethyl)-amino]-methylenmalononitril
  参考文献：
  名称：

  1,1′-Dicyano-2-substituted ethylenes: A new class of glucose uptake inhibitors in antifilarial chemotherapy

  摘要：

  Several 1,1'-dicyano-2-substituted ethylenes (2-16) were synthesized and evaluated for in vivo antifilarial activity. Some of the screened compounds showed significant antifilarial response against Acanthocheilonema viteae in rodents. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00322-3

文献信息

• Synthesis of Potential Antineoplastic Agents. XVIII. Synthesis of New Alkylating Agents
  作者：Frank D. Popp、Frederick P. Silver、Adria C. Noble

  DOI：10.1021/jm00317a074

  日期：1967.9
• 1,1′-Dicyano-2-substituted ethylenes: A new class of glucose uptake inhibitors in antifilarial chemotherapy
  作者：Swati Tewari、P.M.S. Chauhan、A.P. Bhaduri、S.N. Singh、Nigar Fatma、R.K. Chatterjee、V.M.L. Srivastava

  DOI：10.1016/s0960-894x(97)00322-3

  日期：1997.7

  Several 1,1'-dicyano-2-substituted ethylenes (2-16) were synthesized and evaluated for in vivo antifilarial activity. Some of the screened compounds showed significant antifilarial response against Acanthocheilonema viteae in rodents. (C) 1997 Elsevier Science Ltd.