(2S)-N-(2-tetrahydropyranyloxy)-2-[5-(2-thienyl)-2-thienyl]-3,4,5,6-tetrahydro-2H-thiopyran-2-acetamide 1,1-dioxide | 282112-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: (2S)-N-(2-tetrahydropyranyloxy)-2-[5-(2-thienyl)-2-thienyl]-3,4,5,6-tetrahydro-2H-thiopyran-2-acetamide 1,1-dioxide
• 英文别名: 2-[(2S)-1,1-dioxo-2-(5-thiophen-2-ylthiophen-2-yl)thian-2-yl]-N-(oxan-2-yloxy)acetamide
• CAS: 282112-56-5
• 化学式: C₂₀H₂₅NO₅S₃
• 分子量: 455.62
• InChiKey: HDMNMDZQBOQHFC-ANYOKISRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1140895B1

  公开（公告）日：2004-03-24
• [EN] CYCLIC COMPOUND<br/>[FR] COMPOSE CYCLIQUE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000040576A2

  公开（公告）日：2000-07-13

  A compound of formula (I) in which R1 is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R2 is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or optionally substituted heterocyclic group, A is lower alkylene, X is oxa or a single bond, Y is thia, sulfinyl or sulfonyl, Z is methylene, thia, sulfinyl or sulfonyl, m and n are each an integer of 0 to 6, and 1≤m+n≤6, or its salt, which is useful as an inhibitor of matrix metalloproteinases (MMP) or tumor necrosis factor α (TNF α).