8-Isopropyl-4-methyl-9,14-diaza-naphtho[1,2-a]anthracene | 87168-21-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-Isopropyl-4-methyl-9,14-diaza-naphtho[1,2-a]anthracene
• CAS: 87168-21-6
• 化学式: C₂₄H₂₀N₂
• 分子量: 336.436
• InChiKey: JXWJHYUMTHYAGH-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-isopropyl-8-methylphenanthrene-3,4-dione 、 邻苯二胺 在 溶剂黄146 作用下， 生成 8-Isopropyl-4-methyl-9,14-diaza-naphtho[1,2-a]anthracene
  参考文献：
  名称：

  New platelet aggregation inhibitors from Tan-Shen; Radix of Salvia miltiorrhiza Bunge.

  摘要：

  A potent inhibitor (Ro 09-0680) of rabbit platelet aggregation induced by collagen was isolated from a Chinese medicine, Tan-Shen, (radix of Salvia miltiorrhiza) and identified as a novel component, 2-isopropyl-8-methylphenanthrene-3, 4-dione (I). IC50 of I in the previously established assay was 6.6×10-6M, which is 30 times more potent than papaverine. Related diketophenanthrene derivatives such as tanshinone I, tanshinone II and cryptotanshinone were also found to have the inhibitory activity, though to lesser extents.

  DOI：

  10.1248/cpb.31.1670