N-(1,3-benzodioxol-5-ylmethyl)-N-(indan-2-yl)-9H-fluorene-4-carboxamide | 610794-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-(1,3-benzodioxol-5-ylmethyl)-N-(indan-2-yl)-9H-fluorene-4-carboxamide
• 英文别名: N-(1,3-benzodioxol-5-ylmethyl)-N-(2,3-dihydro-1H-inden-2-yl)-9H-fluorene-4-carboxamide
• CAS: 610794-54-2
• 化学式: C₃₁H₂₅NO₃
• 分子量: 459.544
• InChiKey: XMDYUNIDUPSQRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS<br/>[FR] BIARYLAMIDES SUBSTITUES EN TANT QUE MODULATEURS DU RECEPTEUR C5A
  申请人：NEUROGEN CORP

  公开号：WO2003082826A1

  公开（公告）日：2003-10-09

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式I的取代联苯酰胺。这些化合物是配体，可用于调节体内或体外的C5a受体活性，并且在治疗与人类、驯养伴侣动物和家畜动物中的C5a受体病理激活相关的疾病方面特别有用。提供了用于治疗此类疾病的药物组合物和使用它们的方法，以及用于受体定位研究的这类配体的方法。
• Substituted biaryl amides as C5A receptor modulators
  申请人：Gao Yang

  公开号：US20050096358A1

  公开（公告）日：2005-05-05

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了式I的取代联芳酰胺化合物。这些化合物是配体，可用于在体内或体外调节C5a受体活性，并且在治疗与人类、家畜伴侣动物和家畜动物中的C5a受体病理性激活相关的情况中特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的这种配体的使用方法。
• Substituted biaryl amides as C5a receptor modulators
  申请人：Gao Yang

  公开号：US20060178414A1

  公开（公告）日：2006-08-10

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5 a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5 a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式I的取代联苯酰胺化合物。这些化合物是配体，可用于体内或体外调节C5a受体活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理性C5a受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的此类配体的使用方法。
• EP1487796A4
  申请人：——

  公开号：EP1487796A4

  公开（公告）日：2005-11-16
• SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS
  申请人：NEUROGEN CORPORATION

  公开号：EP1487796A1

  公开（公告）日：2004-12-22