[2-(9,11-dimethyl-1,8-dithia-dibenzo[e,h]azulene-2-ylmethoxy)-ethyl]-dimethyl-amine hydrochloride | 374800-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: [2-(9,11-dimethyl-1,8-dithia-dibenzo[e,h]azulene-2-ylmethoxy)-ethyl]-dimethyl-amine hydrochloride
• 英文别名: 2-[(15,17-dimethyl-3,13-dithiatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2(6),4,7,9,11,14,16-octaen-4-yl)methoxy]-N,N-dimethylethanamine;hydrochloride
• CAS: 374800-88-1
• 化学式: C₂₃H₂₅NOS₂*ClH
• 分子量: 432.051
• InChiKey: UNNZJEUGCINHLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
  申请人：Pliva farmaceutska industrija, dionicko drustvo

  公开号：US20030153750A1

  公开（公告）日：2003-08-14

  The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-&agr;) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.

  本发明涉及由公式I表示的二苯并蓝化合物，以及它们的制药制剂，用于抑制哺乳动物在所有过度分泌这些介质的疾病和情况中的肿瘤坏死因子α（TNF-α）和白细胞介素1（IL-1）。本发明的化合物还表现出镇痛作用，可用于缓解疼痛。
• Secreted and transmembrane polypeptides and nucleic acids encoding the same
  申请人：Genentech, Inc.

  公开号：US20020072092A1

  公开（公告）日：2002-06-13

  The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

  本发明涉及新型多肽和编码这些多肽的核酸分子。本发明还提供了包含这些核酸序列的载体和宿主细胞、包含与异源多肽序列融合的本发明多肽的嵌合多肽分子、与本发明多肽结合的抗体以及生产本发明多肽的方法。
• Secreted and transmembrane polypeptides and nucliec acids encodiing the same
  申请人：Genentech, Inc.

  公开号：US20020123463A1

  公开（公告）日：2002-09-05

  The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

  本发明涉及新型多肽和编码这些多肽的核酸分子。本发明还提供了包含这些核酸序列的载体和宿主细胞、包含与异源多肽序列融合的本发明多肽的嵌合多肽分子、与本发明多肽结合的抗体以及生产本发明多肽的方法。
• SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
  申请人：Genentech Inc.

  公开号：EP1210418A1

  公开（公告）日：2002-06-05
• THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1284977B1

  公开（公告）日：2009-06-24