(4αS,5R)-5-[2-(4-bromopyridin-2-yl)-2-hydroxyethyl]-1-(4-fluorophenyl)-4α-methyl-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol | 1299446-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (4αS,5R)-5-[2-(4-bromopyridin-2-yl)-2-hydroxyethyl]-1-(4-fluorophenyl)-4α-methyl-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol
• 英文别名: (4aS,5R)-5-[2-(4-bromopyridin-2-yl)-2-hydroxyethyl]-1-(4-fluorophenyl)-4a-methyl-6,7-dihydro-4H-cyclopenta[f]indazol-5-ol
• CAS: 1299446-42-6
• 化学式: C₂₄H₂₃BrFN₃O₂
• 分子量: 484.368
• InChiKey: OZSVZTXXEFWMOU-YDUIRMPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
  申请人：Mitchell Helen J.

  公开号：US20120214846A1

  公开（公告）日：2012-08-23

  The present invention encompasses compounds of Formula (I): or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.