(20R,22R)-14α-hydroxy-6-oxo-2β,3β:20,22-bis-(isopropylidenedioxy)-27-nor-5β-cholesta-7,24-dien-26-oic acid | 1436870-40-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (20R,22R)-14α-hydroxy-6-oxo-2β,3β:20,22-bis-(isopropylidenedioxy)-27-nor-5β-cholesta-7,24-dien-26-oic acid
• CAS: 1436870-40-4
• 化学式: C₃₂H₄₆O₈
• 分子量: 558.712
• InChiKey: XKHYKNODTOUYSC-PYSRYDRHSA-N

反应信息

• 作为产物：
  描述：

  丙二酸 、 (20R,22R)-14α-hydroxy-2β,3β:20,22-bis(isopropylidenedioxy)-24-oxo-25,26,27-trinor-5β-cholest-7-en-6-one 在 哌啶 、 吡啶 作用下， 反应 3.0h， 以0.07g的产率得到(20R,22R)-14α-hydroxy-6-oxo-2β,3β:20,22-bis-(isopropylidenedioxy)-27-nor-5β-cholesta-7,24-dien-26-oic acid
  参考文献：
  名称：

  Ozonolysis of alkenes and study of reactions of polyfunctional compounds: LXVIII.* synthesis of ω-carboxy derivatives of 20-hydroxyecdysone diacetonide

  摘要：

  Ozonolysis of omega-anhydro-20-hydroxyecdysone diacetonide gave a mixture of 24- and 25-oxo derivatives, and only the first of these (23-carbaldehyde) reacted with malonic acid according to Knoevenagel to give 14 alpha-hydroxy-2 beta,3 beta: 20,22-bis(isopropylidenedioxy)-6-oxo-27-nor-5 beta-cholesta-7,24-dien-26-oic acid. The oxidation of 23-carbaldehyde with ozone, followed by treatment with diazomethane, afforded 20-hydroxy-25,26,27-trinorecdysone-23-carboxylic acid methyl ester diacetonide.

  DOI：

  10.1134/s1070428013040192