2,3-dimethylene-1,4-dioxane | 70517-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2,3-dimethylene-1,4-dioxane
• 英文别名: 2,3-dimethylene-[1,4]dioxane；2,3-Dimethylen-[1,4]dioxan；2,3-Dimethylen-1,4-dioxan；1,4-Dioxane, 2,3-bis(methylene)-；2,3-dimethylidene-1,4-dioxane
• CAS: 70517-24-7
• 化学式: C₆H₈O₂
• 分子量: 112.128
• InChiKey: BMNHEIVPVHWGCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dimethylene-1,4-dioxane 、 2'-(2''-chlorocycloprop-1''-enyl)ethyl acetate 以 四氢呋喃 、 苯 为溶剂， 反应 96.0h， 生成 2'-<(3''α,5''α)-5''-chloro-8'',11''-dioxatricyclo<5.4.0.0^3'',5''>undec-1''(7'')-en-3''-yl>ethyl acetate
  参考文献：
  名称：

  Banwell, Martin G.; Corbett, Madelaine; Gulbis, Jacqueline, Journal of the Chemical Society. Perkin transactions I, 1993, # 8, p. 945 - 964

  摘要：

  DOI：
• 作为产物：
  描述：

  cis-2,3-bis(iodomethyl)-1,4-dioxane 在 sodium hydroxide 、 二乙二醇乙醚 作用下， 生成 2,3-dimethylene-1,4-dioxane
  参考文献：
  名称：

  A New Synthesis and the Stereochemistry of Some 2,3-Disubstituted Dioxanes

  摘要：

  DOI：

  10.1021/ja01571a069

文献信息

• Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10000483B2

  公开（公告）日：2018-06-19

  The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I) or (II), or compositions thereof, for treating or preventing a wide range of diseases (e.g., proliferative diseases (e.g., cancers, benign neoplasms, angiogenesis, inflammatory diseases, autoimmune diseases) and metabolic diseases (e.g., diabetes (e.g., type 2 diabetes, gestational diabetes)) in a subject. Treatment of a subject with a disease using a compound of Formula (I) or (II), or compositions thereof, may downregulate the expression and/or inhibit the activity of a kinase (e.g., a tyrosine kinase, such as a Tec kinase, in particular, bone marrow on X chromosome kinase (BMX)), and therefore, suppress tyrosine kinase singling in the subject.

  本发明提供了新颖的式(I)化合物及其药学上可接受的盐、溶液剂、水合物、多晶型、共晶体、同系物、立体异构体、同位素标记的衍生物、原药及其组合物。还提供了涉及式（I）或（II）化合物或其组合物的方法和试剂盒，用于治疗或预防受试者的多种疾病（如增殖性疾病（如癌症、良性肿瘤、血管生成、炎症性疾病、自身免疫性疾病）和代谢性疾病（如糖尿病（如 2 型糖尿病、妊娠糖尿病））。使用式(I)或(II)化合物或其组合物治疗患有疾病的受试者，可下调激酶（如酪氨酸激酶，如Tec激酶，特别是X染色体上的骨髓激酶（BMX））的表达和/或抑制其活性，从而抑制受试者体内的酪氨酸激酶单体。
• BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20150246913A1

  公开（公告）日：2015-09-03

  The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I) or (II), or compositions thereof, for treating or preventing a wide range of diseases (e.g., proliferative diseases (e.g., cancers, benign neoplasms, angiogenesis, inflammatory diseases, autoimmune diseases) and metabolic diseases (e.g., diabetes (e.g., type 2 diabetes, gestational diabetes)) in a subject. Treatment of a subject with a disease using a compound of Formula (I) or (II), or compositions thereof, may downregulate the expression and/or inhibit the activity of a kinase (e.g., a tyrosine kinase, such as a Tec kinase, in particular, bone marrow on X chromosome kinase (BMX)), and therefore, suppress tyrosine kinase singling in the subject.
• PHOTOELECTRIC CONVERSION ELEMENT AND METHOD OF MANUFACTURING PHOTOELECTRIC CONVERSION ELEMENT
  申请人：SONY CORPORATION

  公开号：US20210193740A1

  公开（公告）日：2021-06-24

  A first photoelectric conversion element according to an embodiment of the present disclosure incudes: a first electrode; a second electrode disposed to be opposed to the first electrode; and a photoelectric conversion layer provided between the first electrode and the second electrode and including a chromophore, fullerene or a fullerene derivative, and a hole-transporting material, in which the chromophore and the fullerene or the fullerene derivative are bonded to each other at least partially via a crosslinking group in the photoelectric conversion layer.
• US7279200B2
  申请人：——

  公开号：US7279200B2

  公开（公告）日：2007-10-09
• US9316631B1
  申请人：——

  公开号：US9316631B1

  公开（公告）日：2016-04-19