N,N'-disalicyl-hydrazine | 86683-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-disalicyl-hydrazine
• 英文别名: N,N'-Disalicyl-hydrazin；N.N'-Bis-(2-oxy-benzyl)-hydrazin；2-[[2-[(2-Hydroxyphenyl)methyl]hydrazinyl]methyl]phenol
• CAS: 86683-16-1
• 化学式: C₁₄H₁₆N₂O₂
• 分子量: 244.293
• InChiKey: LVSRICFYPMOPMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-disalicyl-hydrazine 在 乙醇 、 溶剂黄146 、 sodium nitrite 作用下， 生成 salicylaldehyde-(nitroso-salicylhydrazone)
  参考文献：
  名称：

  Curtius, Journal fur praktische Chemie (Leipzig 1954), 1912, vol. <2> 85, p. 418

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium amalgam 、 乙醇 作用下， 生成 N,N'-disalicyl-hydrazine
  参考文献：
  名称：

  Curtius, Journal fur praktische Chemie (Leipzig 1954), 1912, vol. <2> 85, p. 418

  摘要：

  DOI：

文献信息

• Novel compounds for treatment of cancer and disorders associated with angiogenesis function
  申请人：Neamati Nouri

  公开号：US20060235034A1

  公开（公告）日：2006-10-19

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  治疗癌症和与血管生成功能相关的疾病的新型化合物。还公开了制备这些化合物的方法，包含这些化合物的制药组合物和包装产品，使用这些分子治疗癌症（如白血病，非小细胞肺癌，结肠癌，中枢神经系统癌症，黑色素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管生成功能相关的疾病（如年龄相关性黄斑变性，黄斑营养不良和糖尿病）的方法，监测治疗的方法，基因表达谱分析的方法，以及调节细胞生长，细胞周期，凋亡或基因表达的方法。
• NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION
  申请人：Neamati Nouri

  公开号：US20090093489A1

  公开（公告）日：2009-04-09

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  新型化合物用于治疗癌症和与血管生成功能相关的疾病。还公开了制备这些化合物的方法、含有这些化合物的药物组合物和包装产品、使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关的疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法、监测治疗的方法、基因表达谱分析的方法以及调节细胞生长、细胞周期、细胞凋亡或基因表达的方法。
• Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function
  申请人：Neamati Nouri

  公开号：US20100120781A1

  公开（公告）日：2010-05-13

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  该专利涉及新型化合物，用于治疗癌症和与血管生成功能相关的疾病。还公开了制备这些化合物的方法，含有这些化合物的药物组合物和包装产品，使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关的疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法，监测治疗的方法，基因表达谱分析的方法，以及细胞生长、细胞周期、凋亡或基因表达的调节方法。
• Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function
  申请人：NEAMATI Nouri

  公开号：US20110034472A1

  公开（公告）日：2011-02-10

  Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.

  新型化合物用于治疗癌症和与血管生成功能相关的疾病。还公开了制备这些化合物的方法，含有这些化合物的药物组合物和包装产品，使用这些分子治疗癌症（例如白血病、非小细胞肺癌、结肠癌、中枢神经系统癌症、黑色素瘤、卵巢癌、乳腺癌、肾癌和前列腺癌）和与血管生成功能相关的疾病（例如年龄相关性黄斑变性、黄斑营养不良和糖尿病）的方法，监测治疗的方法，基因表达谱分析的方法，以及调节细胞生长、细胞周期、凋亡或基因表达的方法。
• [EN] NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION<br/>[FR] NOUVEAUX COMPOSES UTILES POUR LE TRAITEMENT DU CANCER ET DES TROUBLES ASSOCIES A LA FONCTION D'ANGIOGENESE
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2006091246A1

  公开（公告）日：2006-08-31

  [EN] Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
  [FR] La présente invention concerne de nouveaux composés utiles pour le traitement du cancer et des troubles associés à la fonction d'angiogenèse; une méthode de préparation des composés, des compositions pharmaceutiques et des produits conditionnés contenant lesdits composés, une méthode d'utilisation de ces molécules pour traiter le cancer (par exemple la leucémie, le cancer bronchopulmonaire 'non à petites cellules'', le cancer du côlon, le cancer du système nerveux central, le mélanome, le cancer de l'ovaire, le cancer du sein, le cancer du rein et le cancer de la prostate) et les troubles associés à la fonction d'angiogenèse (par exemple la dégénérescence maculaire liée à l'âge, la dystrophie maculaire et le diabète), une méthode de surveillance du traitement, une méthode d'établissement de profils de l'expression génique et une méthode de modulation de la croissance cellulaire, du cycle cellulaire, de l'apoptose ou de l'expression génique.