1-amino-octadecan-2-ol | 81646-07-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-amino-octadecan-2-ol
• 英文别名: 1-Amino-2-octadecanol；1-aminooctadecan-2-ol
• CAS: 81646-07-3
• 化学式: C₁₈H₃₉NO
• 分子量: 285.514
• InChiKey: GVERIJPZBUHJMT-UHFFFAOYSA-N

物化性质

• 沸点：
  409.7±18.0 °C(Predicted)
• 密度：
  0.872±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-nitro-octadecan-2-ol 在 溶剂黄146 、 铂 作用下， 20.0 ℃ 、8.53 MPa 条件下， 生成 1-amino-octadecan-2-ol
  参考文献：
  名称：

  Porter; Wood, Journal of the Institute of Petroleum, 1952, vol. 38, p. 877,879

  摘要：

  DOI：

文献信息

• Selective isomerization of 1,2-epoxyalkanes to aldehydes with lithium dialkylamides
  作者：Akira Yanagisawa、Katsutaka Yasue、Hisashi Yamamoto

  DOI：10.1039/c39940002103

  日期：——

  Reaction of a variety of 1,2-epoxyalkanes with 2.5 equiv. of bulky metal amide—lithium 2,2,6,6-tetramethylpiperidide—affords the corresponding aldehydes exclusively in high yields; this is the first example of base-promoted isomerization of monosubstituted epoxides to aldehydes.

  各种1，2-环氧烷与2.5当量的反应。笨重的金属酰胺（2,2,6,6-四甲基哌啶锂）仅以高收率提供相应的醛；这是单取代的环氧化物被碱促进为醛的异构化的第一个例子。
• Method and apparatus for producing synergistic biocide
  申请人：Singleton L. Freddie

  公开号：US20070049642A1

  公开（公告）日：2007-03-01

  An apparatus and methods to produce synergistic mixtures (or combinations) of haloamines to control growth of microorganisms in aqueous systems are disclosed. The apparatus and methods to produce synergistic mixtures entails producing a batch quantity of a haloamine and converting part of the haloamine to a second haloamine species to form the synergistic mixture.

  本发明涉及一种用于控制水系中微生物生长的卤胺协同混合物（或组合物）的装置和方法。制备卤胺协同混合物的装置和方法包括制备一批量的卤胺，并将部分卤胺转化为第二种卤胺物种以形成协同混合物。
• Compositions and methods for increasing drug efficiency
  申请人：Newman James Michael

  公开号：US20050187147A1

  公开（公告）日：2005-08-25

  In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.

  在一种实施例中，提供了增加药物效率的组合物和方法。在某些实施例中，该组合物包含具有以下公式的共轭物：D-L-S，其中D是药物基团；L是非释放性连接基团，可以存在也可以不存在；S是一种蛋白激酶或脂质激酶底物，在靶系统中过度表达、过度活跃或表现出不良活性。
• Amine derivative and dermatologic preparation containing the same
  申请人：Kao Corporation

  公开号：US05723497A1

  公开（公告）日：1998-03-03

  The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.

  本发明涉及以下通式（I）或（II）所表示的胺衍生物：##STR1## 其中，R1表示含杂原子的C1-C40的烃基，可能具有环结构等；R2-R5各自表示C1-C20的烃基、氢或类似物；A1表示##STR2## 或R15-Z16-(CH2)n-；B1表示氢、C1-C10的烃基、氮或类似物；C1表示氢、C1-C10的烃基、氮、醇残基、磷酸残基或类似物；以及含有该胺衍生物的皮肤科制剂；以及制备该胺衍生物的方法。该胺衍生物具有优异的平滑或去除皱纹和改善角质化的效果。
• Pentaerythritol-spiro-bis-phosphite compositions having improved hydrolytic stability
  申请人：Argus Chemical Corporation

  公开号：EP0143464A2

  公开（公告）日：1985-06-05

  Pentaerythritol-spiro-bis-phosphite compositions are provided having an improved hydrolytic stability, comprising (1) a pentaerythritol-spiro-bis-phosphite of the formula: wherein: R, and R2 are selected from the group consisting of alkyl and alkylaryl groups having at least fourteen carbon atoms up to about thirty-six carbon atoms; and (2) a long-chain aliphatic amine in an amount to improve the hydrolytic stability of the phosphite and having the formula: wherein: R3, R4, and R5 are selected from the group consisting of hydrogen; aliphatic (including alkyl and alkenyl) groups having from one to about thirty-six carbon atoms; and hydroxyalkyl having from two to about six carbon atoms; one of R3, R4 and R5 is an aliphatic group having at least fourteen carbon atoms, and the remaining of R3, R4 and R5 are selected from hydrogen, alkyl having from one to four carbon atoms and hydroxyalkyl; and preferably at least one of R3, R4 and R5 is hydroxyalkyl.

  提供了具有更好水解稳定性的季戊四醇螺二亚磷酸组合物，其中包括 (1) 式中的季戊四醇螺二亚磷酸： 其中 R和R2选自由至少具有十四个碳原子至约三十六个碳原子的烷基和烷芳基所组成的组；和 (2) 长链脂肪族胺，其用量可提高亚磷酸酯的水解稳定性，其式为 其中 R3、R4 和 R5 选自由氢、具有一至约三十六个碳原子的脂肪族（包括烷基和烯基）基团和具有二至约六个碳原子的羟烷基组成的组；R3、R4 和 R5 中的一个是具有至少十四个碳原子的脂肪族基团，R3、R4 和 R5 中的其余部分选自由氢、具有一至四个碳原子的烷基和羟烷基；优选 R3、R4 和 R5 中的至少一个是羟烷基。