3-iodo-2-methylimidazo[1,2-a]pyridine-6-carboxylic acid | 1360881-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-iodo-2-methylimidazo[1,2-a]pyridine-6-carboxylic acid
• CAS: 1360881-86-2
• 化学式: C₉H₇IN₂O₂
• 分子量: 302.071
• InChiKey: RLHMCKNPEGSRIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME
  申请人：Gwak Hyung Sub

  公开号：US20130165652A1

  公开（公告）日：2013-06-27

  The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.

  根据本发明的杂环化合物可以治疗和预防炎症性疾病，愈合皮肤伤口，特别是具有恢复受损皮肤屏障、减少炎症和瘙痒等炎症性皮肤疾病中的效果。此外，含有根据本发明的化合物作为活性成分的组合物可用于缓解各种炎症性疾病和PAR-2过度表达的疾病，特别是该组合物可抑制皮肤中PAR-2的活性，因此该组合物可用作具有抗炎功能的组合物，包括特应性皮炎等炎症性皮肤疾病。
• [EN] NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME<br/>[FR] NOUVEAU COMPOSÉ HÉTÉROCYCLIQUE, ET COMPOSITION POUR TRAITER DES MALADIES INFLAMMATOIRES UTILISANT LEDIT COMPOSÉ
  申请人：NEOPHARM CO LTD

  公开号：WO2012026765A2

  公开（公告）日：2012-03-01

  본 발명에 따른 헤테로고리 화합물은 염증성 질환의 치료 및 예방 효과와 피부 상처치유 효과를 지니며, 특히 염증성 피부 질환에 있어 손상된 피부장벽의 회복효과와 염증 완화, 소양증 완화 효과를 나타내며 본 발명의 화합물을 유효성분으로 하는 조성물은 다양한 염증성 질환 및 PAR-2 (protease activated receptor-2) 수용체의 발현이 증가된 질환을 완화하기 위해 사용할 수 있으며, 특히 피부에서 PAR-2의 활성을 저해하여 아토피 피부염 등을 포함한 염증성 피부질환에 있어 항염 기능을 지닌 조성물로서 사용이 가능하다.