4α-Hydroxy-cholest-5-en | 20230-16-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4α-Hydroxy-cholest-5-en
• 英文别名: (4R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-4-ol
• CAS: 20230-16-4
• 化学式: C₂₇H₄₆O
• 分子量: 386.662
• InChiKey: IYDDNBNPULHLAU-ZLLXVZCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4α-Hydroxy-cholest-5-en 在 氢化钾 、 苯 作用下， 生成 cholest-5-en-4β-yl-methyl ether
  参考文献：
  名称：

  关于表胆固醇甲苯磺酸盐的一些反应

  摘要：

  外延胆固醇甲苯磺酸酯在Δ用氢化铝锂还原去3.5 -Cholestadien和Δ 5 -cholesten过来。此外，在Solvolyseversuchen用乙酸酐和乙酸钾甲醇乙酸钾造成的主要动作Δ 3.5 -Cholestadien。在最后提到的实验中，还少量形成了两种异构甲基醚，可能是6-甲氧基胆甾烯-（4）和4β-甲氧基胆甾烯-（5）。

  DOI：

  10.1002/hlca.19520350704
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 4α-Hydroxy-cholest-5-en
  参考文献：
  名称：

  Jones et al., Journal of the Chemical Society, 1955, p. 2876,2883

  摘要：

  DOI：

文献信息

• Reactions of epoxides—XXIV
  作者：B.N. Blackett、J.M. Coxon、M.P. Hartshorn、K.E. Richards

  DOI：10.1016/s0040-4020(01)83247-6

  日期：1969.1

  4α,5α, 4β,5β- and 5β, 6β-Epoxycholestanes give backbone rearranged compounds on BF3-catalysed rearrangement. Solvent changes markedly affect the products of rearrangement. 4α-Hydroxycompounds arise from the 4β,5β-epoxide on BF3-catalysed rearrangement.

  4α，5α，4β，5β-和5β，6β-环氧胆甾烷在BF 3催化的重排作用下产生骨架重排的化合物。溶剂变化明显影响重排产物。4α-羟基化合物由BF 3催化的重排反应中的4β，5β-环氧化合物产生。
• Reduktionen einiger Toluolsulfonsäureester von Steroiden mittels Lithiumaluminiumhydrid
  作者：P. Karrer、H. Asmis、K. N. Sareen、R. Schwyzer

  DOI：10.1002/hlca.19510340406

  日期：——

  In der vorliegenden Abhandlung wurden die Toluolsulfonsäureester einiger Steroide der Reduktion mit LiAlH4 unterworfen. 7-Oxycholestan-tosylester wurde dabei zu Cholestan, 6-Oxy-cholestan -tosylester zu einem Gemisch von Cholestan und 6-Oxy-cholestan reduziert. Im Pregnenolontosylester wurde die Gruppe CH3C6H4SO2O durch LiAlH4 reduktiv entfernt. Der aus Δ4-Cholesten-3,4-diol gewonnene 3-Tosyl-sulfonsäureester

  在挥发性有机化合物中，甲苯磺酸盐还原剂可以还原为LiAlH 4 Unterworfen。7-Oxycholestan-tosylester wurde dabei zu Cholestan，6-Oxy-cholestan-tosylester zu einem Gemisch von Cholestan和6-Oxy-cholestan reduziert。Im Pregnenolontosylester wurde die Gruppe CH 3 C 6 H 4 SO 2 O durch LiAlH 4还原剂。明镜AUSΔ 4 -Cholesten -3,4-二醇gewonnene 3甲苯磺酰基sulfonsäureesterlieferte贝DER Reduktion第三人以的LiAlH 4 3 verschiedene Verbindungen：Cholesten-（5）-OL-（4），EINE
• Evaluation of Time-Resolved PM_2.5 Data in Urban/Suburban Areas of New Jersey
  作者：Nares Chuersuwan、Barbara J. Turpin、Charles Pietarinen

  DOI：10.1080/10473289.2000.10464214

  日期：2000.10

  Time-resolved data is needed for public notification of unhealthful air quality and to develop an understanding of atmospheric chemistry, including insights important to control strategies. In this research, continuous fine particulate matter (PM) mass concentrations were measured with tapered element oscillating microbalances (TEOMs) across New Jersey from July 1997 to June 1998. Data features indicating the influence of local sources and long-distance transport are examined, as well, as differences between 1-hr maxima and 24-hr average concentrations that might be relevant to acute health effects. Continuous mass concentrations were not significantly different from filter-collected gravimetric mass concentrations with 95% confidence intervals during any season. Annual mean PM2.5 concentrations from July 1997 to June 1998 were 17.3, 16.4, 14.1, and 15.3 mug/m(3) at Newark, Elizabeth, New Brunswick, and Camden, NJ, respectively. Monthly averaged 24- and 1-hr daily maximum PM2.5 concentrations suggest the existence of a high PM2.5 (May-October) and a low PM2.5 (November-April) season.PM2.5 magnitudes and temporal trends were very similar across the state during high PM, events. In fact, the between-site coefficients of determination (R-2) for daily PM2.5 measurements were 84-98% for June and July. Additionally, during the most pronounced PM2.5 episode, PM2.5 concentrations closely tracked the daily maximum 1-hr O-3 concentrations. These observations suggest the importance of transport and atmospheric chemistry (i.e., secondary formation) to PM2.5 episodes in New Jersey The influence of local sources was observed in diurnal concentration profiles and annual average between-site differences. Urban wintertime data illustrate that high 1-hr maximum PM2.5 concentrations can occur on low 24-hr PM2.5 days.
• Holland, Herbert L.; Jahangir, Canadian Journal of Chemistry, 1983, vol. 61, p. 2165 - 2170
  作者：Holland, Herbert L.、Jahangir

  DOI：——

  日期：——
• Kohout,L., Collection of Czechoslovak Chemical Communications, 1973, vol. 38, p. 2760 - 2767
  作者：Kohout,L.

  DOI：——

  日期：——