Bis-(2-amino-ethyl)-isopropyl-amine | 30935-65-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Bis-(2-amino-ethyl)-isopropyl-amine
• 英文别名: N'-(2-aminoethyl)-N'-propan-2-ylethane-1,2-diamine
• CAS: 30935-65-0
• 化学式: C₇H₁₉N₃
• 分子量: 145.248
• InChiKey: DICFFIWTSOXDME-UHFFFAOYSA-N

物化性质

• 沸点：
  222 °C(lit.)
• 密度：
  0.88 g/mL at 25 °C(lit.)
• 闪点：
  75 °F

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Bis-(2-amino-ethyl)-isopropyl-amine 、 对甲苯磺酰氯 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以87%的产率得到4-methyl-N-[2-[2-[(4-methylphenyl)sulfonylamino]ethyl-propan-2-ylamino]ethyl]benzenesulfonamide
  参考文献：
  名称：

  Sienkiewicz, Juliusz; Goss, Ewa; Stanczak, Andrzej, Polish Journal of Chemistry, 1990, vol. 64, # 1-6, p. 77 - 86

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[2-[2-(1,3-dioxoisoindol-2-yl)ethyl-propan-2-ylamino]ethyl]isoindole-1,3-dione 、 肼 、 乙醇 生成 Bis-(2-amino-ethyl)-isopropyl-amine
  参考文献：
  名称：

  SIENKIEWICZ, JULIUSZ;GOSS, EWA;STANCZAK, ANDRZEJ, POL. J. CHEM., 64,(1990) N-6, C. 77-86

  摘要：

  DOI：

文献信息

• AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE
  申请人：Raynham Tony Michael

  公开号：US20090247519A1

  公开（公告）日：2009-10-01

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.

  本发明一般涉及治疗化合物领域，更具体地涉及某些氨基乙基氨基芳基（AEAA）化合物，该化合物在抑制蛋白激酶D（PKD）（例如，PKD1、PKD2、PKD3）方面起作用。本发明还涉及包含这些化合物的药物组合物，以及在体外和体内使用这些化合物和组合物来抑制PKD，并用于治疗由PKD介导的疾病和症状，通过抑制PKD而改善的疾病和症状等，包括增殖性疾病如癌症等。
• Derivatives of amphotericin B
  申请人：Sfunga Therapeutics, Inc.

  公开号：US10882883B2

  公开（公告）日：2021-01-05

  Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas, carbamates, and amides according to Formula (I); C3′-substituted C16 ureas, carbamates, and amides according to Formula (II); C16 acyls according to Formula (III); C2′epi-C16 ureas, carbamates, and amides according to Formula (IV); and C16 oxazolidinone derivatives according to Formula (V). Also disclosed are pharmaceutical compositions comprising the AmB derivatives, and therapeutic methods of using the AmB derivatives.

  本发明公开了两性霉素B（AmB）的衍生物，其特点是与AmB相比，治疗指数有所提高。AmB衍生物包括根据式（I）的C16脲、氨基甲酸酯和酰胺；根据式（II）的C3′-取代的C16脲、氨基甲酸酯和酰胺；根据式（III）的C16酰基；根据式（IV）的C2′-环-C16脲、氨基甲酸酯和酰胺；以及根据式（V）的C16噁唑烷酮衍生物。还公开了包含AmB衍生物的药物组合物，以及使用AmB衍生物的治疗方法。
• Synthesis of desosamines
  申请人：President and Fellows of Harvard College

  公开号：US11008358B2

  公开（公告）日：2021-05-18

  The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

  本发明提供脱糖胺和霉菌胺糖类似物和硝基糖及其制备方法。本发明还提供了式(A′)化合物与乙二醛环化得到式(B)硝基糖的方法。本发明提供了制备式(D′)化合物的方法，包括硝基醇环化得到硝基糖，硝基糖还原和烷基化得到脱糖胺、霉菌胺糖或其类似物。
• Macrolides with modified desosamine sugars and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US11535643B2

  公开（公告）日：2022-12-27

  Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.

  本文提供了用于治疗传染性疾病和炎症的式(I)和(I-N)的大环内酯类化合物。本文所述的 14 元酮内酯和 14、15 和 16 元氮杂环丁烷内酯包含改性糖，这些改性糖是去苏胺或霉菌胺糖类似物。还提供了使用本发明大环内酯类药物治疗感染性疾病和炎症的药物组合物和方法。此外，本公开还提供了通过东半部分和西半部分偶联制备大环内酯的方法。
• DRAW SOLUTES COMPRISING ALKYL AMMONIUM SALT COMPOUNDS
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20150165380A1

  公开（公告）日：2015-06-18

  A draw solute includes a water-soluble alkyl ammonium salt compound, the water-soluble alkyl ammonium salt compound including an ionic moiety and at least two ammonium cationic moieties, the ionic moiety including an anion selected from a carbonate anion (COO − ), a sulfonate anion (SO 3 − ), a sulfate anion (SO 4 2− ), a phosphonate anion (PO 3 2− ), and a phosphate anion (PO 4 3− ), and a cation selected from an alkali metal cation and an alkaline earth metal cation.