7-(1-allyl-3-butenyl)-3-(2,4-dichlorophenyl)-8-ethyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione | 532983-00-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-(1-allyl-3-butenyl)-3-(2,4-dichlorophenyl)-8-ethyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
• 英文别名: 3-(2,4-Dichlorophenyl)-8-ethyl-7-hepta-1,6-dien-4-yl-1-methylpurine-2,6-dione
• CAS: 532983-00-9
• 化学式: C₂₁H₂₂Cl₂N₄O₂
• 分子量: 433.337
• InChiKey: XASPKRMACXZZBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands
  申请人：——

  公开号：US20030119831A1

  公开（公告）日：2003-06-26

  Compounds provided herein are 3,7-dihydro-purine-2,6-dione derivatives of Formula (I): 1 Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis or hypoglycemia.

  本文提供的化合物是Formula (I)的3,7-二氢嘌呤-2,6-二酮衍生物。这些化合物特别适用作为CRF受体配体，因此在治疗各种神经相关疾病方面特别有用，如情感障碍、焦虑和抑郁症、头痛、肠易激综合征、创伤后应激障碍、上核性麻痹、免疫抑制、阿尔茨海默病、胃肠疾病、厌食症或其他进食障碍、药物成瘾、药物或酒精戒断症状、炎症性疾病、心血管或心脏相关疾病、生育问题、人类免疫缺陷病毒感染、出血性应激、肥胖、不孕症、头部和脊髓创伤、癫痫、中风、溃疡、肌萎缩性侧索硬化或低血糖症。
• US7098217B2
  申请人：——

  公开号：US7098217B2

  公开（公告）日：2006-08-29