(1-Amino-4-guanidino-butyl)-phosphinic acid | 95691-24-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1-Amino-4-guanidino-butyl)-phosphinic acid
• CAS: 95691-24-0
• 化学式: C₅H₁₅N₄O₂P
• 分子量: 194.173
• InChiKey: QJSNYLAWEFWUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.0
• 重原子数：
  12.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  125.22
• 氢给体数：
  5.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-甲基-2-疏基硫酸脲 、 (1,4-Diamino-butyl)-phosphinic acid 在 三乙胺 作用下， 以 乙醇 、 水 为溶剂， 以90%的产率得到(1-Amino-4-guanidino-butyl)-phosphinic acid
  参考文献：
  名称：

  Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

  摘要：

  Two series of alpha-amino phosphonic and alpha-amino phosphinic analogs of arginine were prepared and tested as inhibitors of nitric oxide synthase (NOS). Two of the analogs were found to possess inhibitory activity for the neuronal isoform of NOS. (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/0960-894x(96)00144-8

文献信息

• Baylis, E. Keith; Campbell, Colin D.; Dingwall, John G., Journal of the Chemical Society. Perkin transactions I, 1984, p. 2845 - 2853
  作者：Baylis, E. Keith、Campbell, Colin D.、Dingwall, John G.

  DOI：——

  日期：——
• Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase
  作者：Marlon Cowart、Elizabeth A. Kowaluk、Kathy L. Kohlhaas、Karen M. Alexander、James F. Kerwin

  DOI：10.1016/0960-894x(96)00144-8

  日期：1996.5

  Two series of alpha-amino phosphonic and alpha-amino phosphinic analogs of arginine were prepared and tested as inhibitors of nitric oxide synthase (NOS). Two of the analogs were found to possess inhibitory activity for the neuronal isoform of NOS. (C) 1996 Elsevier Science Ltd.