obliquol B | 1030593-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: obliquol B
• 英文别名: 4-[(E)-tetradec-4-enyl]benzene-1,2-diol
• CAS: 1030593-25-9
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: JUSVGHZRAMJHHC-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-4-(4-tetradecenyl)veratrole 在 2,6-二叔丁基-4-甲基吡啶 、 碘代三甲硅烷 作用下， 以 氘代氯仿 为溶剂， 反应 24.0h， 以87%的产率得到obliquol B
  参考文献：
  名称：

  Bioactive alkenylphenols from Piper obliquum

  摘要：

  Various parts of Piper obliquum Ruiz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappa B activity by targeting early events in the TNF alpha-induced NF-kappa B inflammatory pathway, which may explain the effects reported for the traditional use of the plant. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.01.018