5-(oxan-4-yl)-1H-1,2,4-triazol-3-amine | 1344229-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 5-(oxan-4-yl)-1H-1,2,4-triazol-3-amine
• CAS: 1344229-83-9
• 化学式: C₇H₁₂N₄O
• 分子量: 168.2
• InChiKey: FKOYPMDLOFWJSA-UHFFFAOYSA-N

物化性质

• 沸点：
  425.0±55.0 °C(Predicted)
• 密度：
  1.306±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  76.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS
  申请人：Nodthera Limited

  公开号：EP3728238A1

  公开（公告）日：2020-10-28
• SUBSTITUTED TRIAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS
  申请人：Verseon Corporation

  公开号：US20160251341A1

  公开（公告）日：2016-09-01

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.
• [EN] DUAL INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS DOUBLEMENT INHIBITEURS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：VERSEON CORP

  公开号：WO2013049591A2

  公开（公告）日：2013-04-04

  There are provided inter alia multisubstituted aromatic compounds which exhibit dual inhibitory action against thrombin (activated blood-coagulation factor II; EC 3.4.21.5) and coagulation factor Xa (activated Stuart-Prower factor, factor Xa, EC 3.4.21.6), and method of use thereof.