2-hydroxy-5-methylacetophenone-2-furoylhydrazone | 384844-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-hydroxy-5-methylacetophenone-2-furoylhydrazone
• 英文别名: HMAFH
• CAS: 384844-45-5
• 化学式: C₁₄H₁₄N₂O₃
• 分子量: 258.277
• InChiKey: RATKCUMCDMZLRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.02
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  78.32
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-hydroxy-5-methylacetophenone-2-furoylhydrazone 、 manganese(III) triacetate dihydrate 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 [Mn(CH₃COO)(CH₃C₆H₃(O)C(CH₃)NNC(O)C₄H₃O)(H₂O)]
  参考文献：
  名称：

  Hydrazone as complexing agent: Synthesis, structural characterization and biological studies of some complexes

  摘要：

  This paper deals with the synthesis, magnetic, spectral, thermal, and biological studies of Ti(III), VO(IV), Cr(III), Mn(III), Fe(III), and Zr(IV) complexes with chelating hydrazone derived from 2-hydroxy-5-methylacetophenone and furoic acid hydrazide. The acid hydrazone synthesized is 2-hydroxy-5-methylace-tophenone-furoylhydrazone. The ligand has been characterized on the basis of IR and H-1 NMR spectra. The presence of water molecules and thermal stabilities of the complexes are also reported. Solid-state electrical conductivity was measured over a 313-410-K temperature range, and the compounds show semiconducting behavior. The new complexes have been screened for their antibacterial and antifungal activity, and they show higher activity than free ligands.

  DOI：

  10.1134/s0036023607080086
• 作为产物：
  描述：

  2-呋喃甲酰肼 、 2-羟基-5-甲基苯乙酮 以 乙醇 为溶剂， 反应 4.0h， 以80%的产率得到2-hydroxy-5-methylacetophenone-2-furoylhydrazone
  参考文献：
  名称：

  Yaul, Amit R.; Dhande, Vijaya V.; Aswar, Anand S., Revue Roumaine de Chimie, 2010, vol. 55, # 9, p. 537 - 542

  摘要：

  DOI：