(3R)-8-methoxy-3,4-dihydro-2H-chromen-3-amine | 164322-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (3R)-8-methoxy-3,4-dihydro-2H-chromen-3-amine
• CAS: 164322-65-0
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD09026807
• 分子量: 179.219
• InChiKey: YPFAOXHRMCVHOP-MRVPVSSYSA-N

物化性质

• 沸点：
  299.3±40.0 °C(Predicted)
• 密度：
  1.128±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-8-methoxy-3,4-dihydro-2H-chromen-3-amine 在 三氟二甲基硫醚络合物 、 montmorillonite K-10 、 sodium cyanoborohydride 作用下， 生成 (3R)-3-(dipropylamino)-3,4-dihydro-2H-chromen-8-ol
  参考文献：
  名称：

  Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT₇ Receptor Agonists and Antagonists

  摘要：

  The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through this receptor. In this report, we describe two compound classes, chromans and tetralins, encompassing compounds with nanomolar affinity for the 5-HT7 receptor and with good selectivity. Within theses classes, we have discovered both agonists and antagonists that can be used for further understanding of the pharmacology of the 5-HT7 receptor.

  DOI：

  10.1021/jm0498102
• 作为产物：
  描述：

  8-甲氧基-2H-苯并吡喃-3-甲腈 在 盐酸 、 sodium hydroxide 、 palladium on activated charcoal 、 叠氮磷酸二苯酯 、 甲酸铵 、 sodium cyanoborohydride 、 potassium carbonate 、 溶剂黄146 、 三乙胺 、 potassium iodide 作用下， 生成 (3R)-8-methoxy-3,4-dihydro-2H-chromen-3-amine
  参考文献：
  名称：

  Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT₇ Receptor Agonists and Antagonists

  摘要：

  The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through this receptor. In this report, we describe two compound classes, chromans and tetralins, encompassing compounds with nanomolar affinity for the 5-HT7 receptor and with good selectivity. Within theses classes, we have discovered both agonists and antagonists that can be used for further understanding of the pharmacology of the 5-HT7 receptor.

  DOI：

  10.1021/jm0498102

文献信息

• DERIVATIVES OF BENZOPYRAN AND OF BENZOTHIOPYRAN, THEIR PREPARATION AND THEIR USE AS AGONISTS OF DOPAMINERGIC RECEPTORS
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0781280B1

  公开（公告）日：2002-11-06
• [EN] DERIVATIVES OF BENZOPYRAN AND OF BENZOTHIOPYRAN, THEIR PREPARATION AND THEIR USE AS AGONISTS OF DOPAMINERGIC RECEPTORS<br/>[FR] DERIVES DE BENZOPYRANE ET DE BENZOTHIOPYRANE, LEUR PREPARATION AINSI QUE LEUR UTILISATION EN TANT QU'AGONISTES DES RECEPTEURS DOPAMINERGIQUES
  申请人：ZAMBON GROUP S.P.A.

  公开号：WO1996008489A1

  公开（公告）日：1996-03-21

  (EN) Compounds of formula (I), wherein R, R', R', Z, m, Y, n, R1, X, p and Ar have the meanings reported in the description; and pharmaceutically acceptable salts thereof are described. The compounds of formula (I) are useful in the treament of arterial hypertension and heart failure, of renal failure, of peripheral arteriopathies, of cerebrovascular insufficiencies and of ischemic cardiopathy.(FR) Composés de la formule (I), ainsi que leurs sels acceptables sur le plan pharmacologique, formule dans laquelle R, R', R', Z, m, Y, n, R1, X, p et Ar ont les notations données dans la description. Les composés de la formule (I) sont utiles dans le traitement de l'hypertension artérielle et de l'insuffisance cardiaque, de l'insuffisance rénale, des artériopathies périphériques, des insuffisances vasculaires cérébrales ainsi que de la cardiopathie ischémique.