Diethyl-(3-iodo-propyl)-amine | 79156-87-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Diethyl-(3-iodo-propyl)-amine
• 英文别名: N,N-diethyl-3-iodopropan-1-amine
• CAS: 79156-87-9
• 化学式: C₇H₁₆IN
• 分子量: 241.115
• InChiKey: XKRQLFAFMZSNJH-UHFFFAOYSA-N

物化性质

• 沸点：
  202.6±23.0 °C(Predicted)
• 密度：
  1.416±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Diethyl-(3-iodo-propyl)-amine 、 methoxy-5 (dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 8.0h， 以38.2%的产率得到2-[1-[3-(diethylamino)propyl]pyridin-4-ylidene]-5-methoxyindene-1,3-dione
  参考文献：
  名称：

  Pyrophtalones VII. Synthèse et activité anti-inflammatoire de (pyridinyl-4)-2 indanediones-1,3 substituées sur le noyau benzénique et/ou sur l'hétérocycle

  摘要：

  DOI：

  10.1016/0223-5234(87)90054-7

文献信息

• [EN] MULTI-TAILED LIPIDS AND USES THEREOF<br/>[FR] LIPIDES À QUEUES MULTIPLES ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014210356A1

  公开（公告）日：2014-12-31

  The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, plasmid DNA, small molecule, protein, peptide). The present invention also provides methods, and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases (e.g., liver diseases), respiratory diseases (e.g., lung diseases), painful conditions, psychiatric disorders, metabolic disorders, and spleen diseases.

  本发明提供了多尾脂类化合物，以及其盐和立体异构体，以及制备该化合物的方法。还提供了包括本发明化合物和药剂（例如siRNA，mRNA，质粒DNA，小分子，蛋白质，肽）的组合物。本发明还提供了使用该组合物进行将药剂输送到受体（例如受体的肝脏，脾脏或肺部）或细胞以及治疗和/或预防一系列疾病的方法，例如遗传性疾病，增生性疾病，血液疾病，神经系统疾病，免疫性疾病，胃肠疾病（例如肝病），呼吸系统疾病（例如肺病），疼痛症状，精神障碍，代谢性疾病和脾疾病。
• 3-Aminoindazole derivatives and process for preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0049779A1

  公开（公告）日：1982-04-21

  A compound of the formula (I): wherein W, is a hydrogen atom or a group wherein Y is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-6 alkyl group and R,, R2 and the adjacent nitrogen atom may form a C4-6 heterocyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; W2 is a hydrogen atom or a group wherein Z is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R3 and R4 each independently is a hydrogen atom or a C1-6 alkyl group and R3, R4 and the adjacent nitrogen atom may form a C4-6 hetercyclic ring or a C4-6 heterocyclic ring containing an additional nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; when W, is a hydrogen atom, W2 is the group; and when W2 is a hydrogen atom, W, is the group; and the pharmaceutically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W，是氢原子或 其中 Y 是 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；R 和 R2 各自独立地是氢原子或 C1-6 烷基，且 R、R2 和相邻的氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； W2 是氢原子或 其中 Z 为 C1-6 亚烷基或具有 C1-6 烷基取代基的 C1-6 亚烷基；以及 R3 和 R4 各自独立地为氢原子或 C1-6 烷基，且 R3、R4 和相邻氮原子可形成 C4-6 杂环或含有额外氮原子的 C4-6 杂环，且 C4-6 杂环可具有至少一个 C1-6 烷基、羟基或卤素原子； 当 W 是氢原子时，W2 是 基团；以及 当 W2 是氢原子时，W, 是基团；及 基团；及其药学上可接受的酸加成盐。
• Indazole derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0090972A2

  公开（公告）日：1983-10-12

  A compound of the formula (I): wherein W, and W2 each independently is a hydrogen atom or a group wherein Y is a n-C1-6 alkvlene group or a n-C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-5 alkyl group, and group in group may form a saturated heterocyclic ring selected from the group consisting of morphohno. pyrrolidino, piperidino, homopiperidino and piperazino groups. and the saturated heterocyclic ring except the morpholino group may have at least one C1-4 alkyl group, hydroxyl group or halogen atom as a substituent; Z, is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C1-3 alkyl group or a methoxy group; Z2 is a hydrogen atom or an amino group; when W, and W2 are both hydrogen atoms, Z, is a hydroxyl group or an iodine atom and Z2 is hydrogen atom, or Z, and 22 are both amino groups; When Z, and 22 are both hydrogen atoms, the group in either W, or W2 is a morpholino group; when Z, is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z2 is a hydrogen atom; when Z, is an amino group, Z2 is a hydrogen atom or an amino group; when Z, is a methyl group, a methoxy group or an amino group, Z, is in the 5-position; when Z, is an iodine atom, Z, is in the 5- or 7-position; and when Z, and Z2 are both amino groups. Z, and Z2 are in the 5- and 7-positions; and the physiologically acceptable acid addition salt thereof.

  式 (I) 的化合物： 其中 W和W2各自独立地为氢原子或基团，其中 其中 Y 是 n-C1-6 烯基或具有 C1-6 烷基取代基的 n-C1-6 烯基；以及 R 和 R2 各自独立地是氢原子或 C1-5 烷基，且 中的基团 除吗啉基外，饱和杂环可具有至少一个 C1-4 烷基、羟基或卤原子作为取代基； Z 是氢原子、氯原子、溴原子、碘原子、羟基、氨基、C1-3 烷基或甲氧基； Z2 是氢原子或氨基； 当 W 和 W2 都是氢原子时，Z 是羟基或碘原子，Z2 是氢原子，或 Z 和 22 都是氨基； 当 Z 和 22 均为氢原子时，则 当 Z 和 22 均为氢原子时，W 或 W2 中的基团为吗啉基； 当 Z 为氯原子、羟基、碘原子、甲基或甲氧基时，Z2 为氢原子； 当 Z 为氨基时，Z2 为氢原子或氨基； 当 Z 是甲基、甲氧基或氨基时，Z 在 5 位；当 Z 是碘原子时，Z 在 5 或 7 位；当 Z 和 Z2 都是氨基时。Z和Z2分别位于5和7位；及其生理学上可接受的酸加成盐。
• Tead inhibitors and uses thereof
  申请人：Ikena Oncology, Inc.

  公开号：US11274082B2

  公开（公告）日：2022-03-15

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof
  申请人：ELI LILLY AND COMPANY

  公开号：EP0018076B1

  公开（公告）日：1983-09-21