branched polyethyleneimine | 86239-28-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: branched polyethyleneimine
• 英文别名: Ethylazanide
• CAS: 86239-28-3
• 化学式: C₂H₅N
• 分子量: 43.0684
• InChiKey: KHWFNDACINYGNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  3.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.8
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  branched polyethyleneimine 、 [Cu(1,10-phenanthroline)(L-theronine)(H2O)]ClO4 、 水 以 乙醇 、 水 为溶剂， 生成 ([Cu(1,10-phenanthroline)(L-theronine)(branched polyethyleneimine)]ClO4*2H2O)0.169(branched polyethyleneimine)0.831
  参考文献：
  名称：

  DNA binding and antimicrobial studies of some polyethyleneimine-copper(II) complex samples containing 1,10-phenanthroline and l-theronine as co-ligands

  摘要：

  The polymer-copper(II) complex samples, [Cu(phen)(L-Thr)(BPEI)]ClO4 center dot 2H(2)O (L-Thr = L-theronine, phen = 1, 10-phenanthroline and BPEI = branched polyethyleneimine), with varying degrees of copper(II) chelate content in the polymer chain, were prepared by ligand substitution method in water-ethanol medium and characterized by Infra-red, UV-Vis, EPR spectral and elemental analysis methods. The binding of these complex samples with calf thymus DNA (CT-DNA) has been investigated by absorption spectroscopy and emission spectroscopy and gel electrophoresis techniques. The experimental results indicate that the polymer-copper(II) complex is an avid DNA binder and the binding constant increased with the increase in amount of copper(II) chelate content in the polymer chain. Besides the electrostatic interaction between a negatively charged DNA molecule and a positively charged polymer-copper(II) complex molecule, other binding modes, such as van der Waals interaction, hydrogen bonding and partial intercalation binding modes may also exist in this system. A sample of polymer-copper(II) complex was tested for its antibacterial and antifungal activity and it was found to have good antibacterial and antifungal activities. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.001

文献信息

• Synthesis, characterization and DNA binding studies of a polymer-cobalt(III) complex containing the 2,2′-bipyridyl ligand
  作者：R. Senthil Kumar、S. Arunachalam

  DOI：10.1016/j.poly.2006.05.043

  日期：2006.11

  The polymer-cobalt(III) complex, cis-[Co(bpy)(2)(BPEI)Cl]Cl-2 center dot 4H(2)O (bpy = 2,2'-bipyridine, BPEI = branched polyethyleneimine) has been synthesised and characterized. Binding of this polymer-cobalt(III) complex with calf thymus DNA(CT-DNA) was investigated by UV-Visible absorption and fluorescence spectroscopic techniques. Also the interaction of pBR322 DNA with the same polymer-cobalt(III) complex was studied using the gel electrophoresis method. The results indicate that the polymer-cobalt(III) complex interacts with DNA very strongly (K-b = 5.12 x 10(5) M-' and K-sv = 0.2023). The nature of the binding seems to be mainly an electrostatic interaction between DNA and the polymer-cobalt(III) complex. Other binding modes, such as hydrogen bonds, may also exist in this system. The high binding constant values indicate the operation of cooperative effects between multiple cobalt(III) complex molecular units and free amine groups, which are present in a single polymer molecule, in binding to DNA. (C) 2006 Elsevier Ltd. All rights reserved.
• DNA binding and antimicrobial studies of some polyethyleneimine-copper(II) complex samples containing 1,10-phenanthroline and l-theronine as co-ligands
  作者：R. Senthil Kumar、S. Arunachalam

  DOI：10.1016/j.poly.2007.03.001

  日期：2007.8

  The polymer-copper(II) complex samples, [Cu(phen)(L-Thr)(BPEI)]ClO4 center dot 2H(2)O (L-Thr = L-theronine, phen = 1, 10-phenanthroline and BPEI = branched polyethyleneimine), with varying degrees of copper(II) chelate content in the polymer chain, were prepared by ligand substitution method in water-ethanol medium and characterized by Infra-red, UV-Vis, EPR spectral and elemental analysis methods. The binding of these complex samples with calf thymus DNA (CT-DNA) has been investigated by absorption spectroscopy and emission spectroscopy and gel electrophoresis techniques. The experimental results indicate that the polymer-copper(II) complex is an avid DNA binder and the binding constant increased with the increase in amount of copper(II) chelate content in the polymer chain. Besides the electrostatic interaction between a negatively charged DNA molecule and a positively charged polymer-copper(II) complex molecule, other binding modes, such as van der Waals interaction, hydrogen bonding and partial intercalation binding modes may also exist in this system. A sample of polymer-copper(II) complex was tested for its antibacterial and antifungal activity and it was found to have good antibacterial and antifungal activities. (c) 2007 Elsevier Ltd. All rights reserved.