di-tert-butyl 4-methylhexahydropyridazine-1,2-dicarboxylate | 1161001-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: di-tert-butyl 4-methylhexahydropyridazine-1,2-dicarboxylate
• 英文别名: Ditert-butyl 4-methyldiazinane-1,2-dicarboxylate；ditert-butyl 4-methyldiazinane-1,2-dicarboxylate
• CAS: 1161001-04-2
• 化学式: C₁₅H₂₈N₂O₄
• 分子量: 300.398
• InChiKey: SVKNSDYRAUTJMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  di-tert-butyl 4-methylhexahydropyridazine-1,2-dicarboxylate 在 sodium periodate 、 (x)H₂O*O₂Ru 作用下， 以 水 、 乙酸乙酯 为溶剂， 以33%的产率得到di-tert-butyl 5-methyl-3-oxohexahydropyridazine-1,2-dicarboxylate
  参考文献：
  名称：

  Ruthenium Tetroxide Oxidation of N,N’-DiBoc-Hexahydropyridazines

  摘要：

  The ruthenium tetroxide (RuO4) oxidation of the 3-substituted N,N'-diBochexahydropyridazines gave the 6-oxohexahydropyridazines in good to high yields, whereas the oxidation of the unsubstituted ones also gave the 3,6-dioxo derivatives. The 3,6-cis-disubstituted pyridazines were essentially oxidized to give the 3-hydroxypyridazines; no oxidation of the trans-derivative occurred.

  DOI：

  10.3987/com-08-s(d)31
• 作为产物：
  描述：

  di-tert-butyl 4-methyl-1,2,3,6-tetrahydropyridazine-1,2-dicarboxylate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、506.66 kPa 条件下， 以87%的产率得到di-tert-butyl 4-methylhexahydropyridazine-1,2-dicarboxylate
  参考文献：
  名称：

  Ruthenium Tetroxide Oxidation of N,N’-DiBoc-Hexahydropyridazines

  摘要：

  The ruthenium tetroxide (RuO4) oxidation of the 3-substituted N,N'-diBochexahydropyridazines gave the 6-oxohexahydropyridazines in good to high yields, whereas the oxidation of the unsubstituted ones also gave the 3,6-dioxo derivatives. The 3,6-cis-disubstituted pyridazines were essentially oxidized to give the 3-hydroxypyridazines; no oxidation of the trans-derivative occurred.

  DOI：

  10.3987/com-08-s(d)31

文献信息

• Ruthenium Tetroxide Oxidation of N,N’-DiBoc-Hexahydropyridazines
  作者：Haruki Sashida、Shigeyuki Yoshifuji、Mamoru Kaname

  DOI：10.3987/com-08-s(d)31

  日期：——

  The ruthenium tetroxide (RuO4) oxidation of the 3-substituted N,N'-diBochexahydropyridazines gave the 6-oxohexahydropyridazines in good to high yields, whereas the oxidation of the unsubstituted ones also gave the 3,6-dioxo derivatives. The 3,6-cis-disubstituted pyridazines were essentially oxidized to give the 3-hydroxypyridazines; no oxidation of the trans-derivative occurred.