(S)-2-(1-nitrobutan-2-yl)naphthalene | 1233704-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-2-(1-nitrobutan-2-yl)naphthalene
• CAS: 1233704-22-7
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: DMOCEMHXMPFNEZ-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.14
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-(2-nitrovinyl)naphthalene 、 diethylzinc 在 C₄₈H₅₀N₂O₄P₂ 、 copper(II) acetate monohydrate 作用下， 以 甲苯 为溶剂， 生成 (S)-2-(1-nitrobutan-2-yl)naphthalene 、 (R)-2-(1-nitrobutan-2-yl)naphthalene
  参考文献：
  名称：

  From C2- to D2-symmetry: atropos phosphoramidites with a D2-symmetric backbone as highly efficient ligands in Cu-catalyzed conjugate additions

  摘要：

  Atropos phosphoramidites with the D-2-symmetric biphenyl backbone were diastereoselectively prepared with ease from achiral tetrahydroxy biphenyls. This type of ligands is proved to be highly efficient in the Cu-catalyzed conjugate additions of diethylzinc to alpha,beta-unsaturated ketones and nitroalkenes. The unique D-2-symmetric backbone endows the ligands with an excellent chiral environment. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.033

文献信息

• Chiral NHC ligands bearing a pyridine moiety in copper-catalyzed addition of diethylzinc to nitroalkenes
  作者：Takahiro Soeta、Yuichi Hatanaka、Tomohiro Ishizaka、Yutaka Ukaji

  DOI：10.1016/j.tet.2018.07.030

  日期：2018.8

  Chiral N-heterocyclic carbenes, derived from amino acids containing a pyridine ring, are effective ligands in the enantioselective copper-catalyzed addition of diethylzinc to beta-nitroalkenes, which provides access to chiral nitroalkanes. The advantages of this process include high yields, broad and complementary substrate scope, and good to high enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.