| 1399820-41-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• CAS: 1399820-41-7
• 化学式: C₁₈H₂₄N₃O₇PS
• 分子量: 457.444
• InChiKey: XHCDISKAOOIYQI-HIJUVRQPSA-N

反应信息

• 作为产物：
  描述：

  在 氨 、 甲胺 作用下， 反应 0.17h， 生成 、
  参考文献：
  名称：

  Oxidation of H-Phosphonates with Iodine by Intramolecular Support of a 2-Pyridyl Thermolabile Protecting Group

  摘要：

  Acceleration of H-phosphonate diester oxidation with iodine accompanied by a thermolabile protecting group (TPG) is presented. It is shown that the intermediate product of this reaction is an oxazaphospholidine oxide which forms a phosphate diester only when a 2-pyridyl TPG is applied. The intermediate product is formed with exocyclic nitrogen. The absolute configurations of phosphorothioate diesters, H-phosphonate diesters, and oxazaphospholidine oxides were determined. P-31 NMR spectroscopy was used to evaluate the relationship between chemical shift and absolute configuration at the phosphorus center of H-phosphonate diesters and oxazaphospholidine oxides.

  DOI：

  10.1021/jo300937k